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CYP20A1
Identifiers
Aliases	CYP20A1, CYP-M, cytochrome P450 family 20 subfamily A member 1
External IDs	MGI: 1925201; HomoloGene: 18584; GeneCards: CYP20A1; OMA:CYP20A1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.2 Start 203,238,940 bp End 203,305,611 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C2 Start 60,382,482 bp End 60,427,219 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gonad epithelium of colon monocyte islet of Langerhans testicle body of pancreas rectum right adrenal cortex left adrenal gland Top expressed in umbilical cord seminal vesicula calvaria ureter cumulus cell renal corpuscle left lung lobe dermis trigeminal ganglion interventricular septum More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 57404 77951 Ensembl ENSG00000119004 ENSMUSG00000049439 UniProt Q6UW02 Q8BKE6 RefSeq (mRNA) NM_020674 NM_177538 NM_030013 NM_001313721 RefSeq (protein) NP_803882 NP_001358624 NP_001358625 NP_001358626 NP_001358627 NP_001358628 NP_001358629 NP_001358630 NP_001358631 NP_001358632 NP_001358633 NP_001358634 NP_001358635 NP_001300650 NP_084289 Location (UCSC) Chr 2: 203.24 – 203.31 Mb Chr 1: 60.38 – 60.43 Mb PubMed search
Wikidata
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CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in pollutant and drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP20A1 lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.

CYP20A1 has no identified substrate or biological role and is considered an "orphan" P450.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000119004 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000049439 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
6.  This article incorporates public domain material from "Entrez Gene: CY20A1". Reference Sequence collection. National Center for Biotechnology Information.

External links

• Human CYP20A1 genome location and CYP20A1 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiang JH, Jia WH, Qin HD, et al. (2004). "". AI Zheng. 23 (6): 672–7. PMID 15191668.
• Werck-Reichhart D, Feyereisen R (2000). "Cytochromes P450: a success story". Genome Biol. 1 (6): REVIEWS3003. doi:10.1186/gb-2000-1-6-reviews3003. PMC 138896. PMID 11178272.
• Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy". Nat. Genet. 41 (12): 1345–9. doi:10.1038/ng.478. PMID 19898482. S2CID 21293339.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
• Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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