Misplaced Pages

In enzymology, a dephospho-CoA kinase (EC 2.7.1.24) is an enzyme that catalyzes the chemical reaction

ATP + dephospho-CoA ${\displaystyle \rightleftharpoons }$ ADP + CoA

Thus, the two substrates of this enzyme are ATP and dephospho-CoA, whereas its two products are ADP and CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:dephospho-CoA 3'-phosphotransferase. Other names in common use include dephosphocoenzyme A kinase (phosphorylating), 3'-dephospho-CoA kinase, and dephosphocoenzyme A kinase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1JJV, 1N3B, 1T3H, 1VHL, 1VHT, 1VIY, 2GRJ, and 2IF2.

References

• Abiko Y (1970). "Pantothenic acid and coenzyme A: Dephospho-CoA pyrophosphorylase and dephospho-CoA kinase as a possible bifunctional enzyme complex (ATP: Pantetheine-4′-phosphate adenyltransferase, EC 2.7.7.3 and ATP: Dephospho-CoA 3′-phosphotransferase, EC 2.7.1.24)". Vitamins and Coenzymes. Methods Enzymol. Vol. 18A. pp. 358–364. doi:10.1016/0076-6879(71)18327-9. ISBN 978-0-12-181879-1.
• HOAGLAND MB, NOVELLI GD (1954). "Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate". J. Biol. Chem. 207 (2): 767–73. doi:10.1016/S0021-9258(18)65696-0. PMID 13163064.
• Wang TP, Kaplan NO (1954). "Kinases for the synthesis of coenzyme A and triphosphopyridine nucleotide". J. Biol. Chem. 206 (1): 311–325. doi:10.1016/S0021-9258(18)71320-3. PMID 13130551.

• Biology

• v
• t
• e

• EC 2.7.1
• Enzymes of known structure
• EC 2.7 stubs