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Diflucortolone valerate

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Diflucortolone valerate
Names
IUPAC name 6α,9-Difluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate
Systematic IUPAC name 2-phenanthren-1-yl]-2-oxoethyl pentanoate
Other names Afusona; Diflucortolone 21-valerate
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.056.032 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1Key: HHJIUUAMYGBVSD-YTFFSALGSA-N
  • InChI=1/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1Key: HHJIUUAMYGBVSD-YTFFSALGBY
SMILES
  • O=C(OCC(=O)32(C(O)4(F)/1(\C(=C/C(=O)\C=C\1)(F)C42C3C)C)C)CCCC
Properties
Chemical formula C27H36F2O5
Molar mass 478.577 g·mol
Melting point 220 °C (428 °F; 493 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Diflucortolone valerate (also Nerisone cream/ointment/fatty ointment, Neriderm ointment, Japanese ジフルコルトロン (Jifurucorutoron)) is a corticosteroid rated Class 3 "potent" (100–150 times) in the New Zealand topical steroid system. It is a white to creamy white crystalline powder. It is practically insoluble in water, freely soluble in dichloromethane and in dioxan, sparingly soluble in ether and slightly soluble in methyl alcohol. Chemically, it is a corticosteroid esterified with valeric acid. It is commonly used topically in dermatology. The brand name is Nerisone; its creams come in potencies of 0.1% and 0.3%.

See also

References

  1. Chemlink Diflucortolone valerate


Glucocorticoids and antiglucocorticoids (D07, H02)
Glucocorticoids
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Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
Glucocorticoid receptor modulators
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(SEGRMsTooltip Selective glucocorticoid receptor agonists)
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See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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