Pharmaceutical compound
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Trade names | Lyfnua |
Other names | MK-7264 |
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ECHA InfoCard | 100.258.106 |
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Formula | C14H19N5O4S |
Molar mass | 353.40 g·mol |
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Gefapixant, sold under the brand name Lyfnua, is a medication used to treat chronic (long-term) cough. It acts as an antagonist of the P2RX3 receptor.
It was approved for medical use in the European Union in September 2023.
Medical uses
Gefapixant is indicated for the treatment of refractory or unexplained chronic cough.
Society and culture
Names
It was named in honour of Geoff Burnstock.
References
- ^ "Lyfnua EPAR". European Medicines Agency. 29 September 2023. Retrieved 5 October 2023.
- Muccino D, Green S (June 2019). "Update on the clinical development of gefapixant, a P2X3 receptor antagonist for the treatment of refractory chronic cough". Pulmonary Pharmacology & Therapeutics. 56: 75–78. doi:10.1016/j.pupt.2019.03.006. PMID 30880151. S2CID 81982653.
- Richards D, Gever JR, Ford AP, Fountain SJ (July 2019). "Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation". British Journal of Pharmacology. 176 (13): 2279–2291. doi:10.1111/bph.14677. PMC 6555852. PMID 30927255.
- Marucci G, Dal Ben D, Buccioni M, Martí Navia A, Spinaci A, Volpini R, et al. (December 2019). "Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications". Expert Opinion on Therapeutic Patents. 29 (12): 943–963. doi:10.1080/13543776.2019.1693542. hdl:11581/435751. PMID 31726893. S2CID 208037373.
- Ford AP, Dillon MP, Kitt MM, Gever JR (November 2021). "The discovery and development of gefapixant". Autonomic Neuroscience. 235: 102859. doi:10.1016/j.autneu.2021.102859. PMID 34403981. S2CID 236524967.
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