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Gilbert Stork (December 31, 1921 – October 21, 2017) was a Belgian-American organic chemist. For a quarter of a century he was the Eugene Higgins Professor of Chemistry Emeritus at Columbia University. He is known for making significant contributions to the total synthesis of natural products, including a lifelong fascination with the synthesis of quinine. In so doing he also made a number of contributions to mechanistic understanding of reactions, and performed pioneering work on enamine chemistry, leading to development of the Stork enamine alkylation. It is believed he was responsible for the first planned stereocontrolled synthesis as well as the first natural product to be synthesised with high stereoselectivity.

Stork was also an accomplished mentor of young chemists and many of his students have gone on to make significant contributions in their own right.

Early life

Gilbert Stork was born in the Ixelles municipality of Brussels, Belgium on December 31, 1921. The oldest of 3 children, his middle brother, Michel, died in infancy, but he remained close with his younger sister Monique his whole life. His family had Jewish origins, although Gilbert himself didn't recall them being religiously active. The family moved to Nice when Gilbert was about 14 (circa. 1935) and remained there until 1939. During this period, Gilbert completed his lycée studies, distinguishing himself in French literature and writing. Characterizing himself during those years as "not terribly self-confident," and uncertain whether he could find employment in a profession he enjoyed, Gilbert considered applying for a colonial civil service job in French Indochina. However, the outbreak of World War II that year led the family to flee to New York, where his father's older brother, Sylvain, had already emigrated.

Education

Gilbert studied for a Bachelor of Science at the University of Florida, from 1940 to 1942. He then moved to the University of Wisconsin–Madison for this PhD, which he obtained in 1945 under the supervision of Samuel M. McElvain. While at Wisconsin he met Carl Djerassi, with whom he would go on to form a lasting friendship.

Career

• 1946 Harvard University: Instructor; 1948 Assistant Professor
• 1953 Columbia University: Associate Professor; 1955 Professor; 1967–1993 Eugene Higgins Professor; *1993 Professor Emeritus

Elected to

• U.S. National Academy of Sciences, 1961
• American Academy of Arts and Sciences, 1962
• Foreign Member of the French Academy of Sciences, 1989
• American Philosophical Society, 1995
• The Royal Society, UK 1999

Incidents

The explosive steak

During his time at the University of Wisconsin, Stork kept a steak on his windowsill in the winter in order to keep it refrigerated. The steak began to degrade and to dispose of it Stork put it in a hot acid bath used to clean glassware which contained nitric and sulphuric acids. He was then concerned he would produce nitroglycerine due to the glycerine in the steak and the presence of nitric and sulphuric acids. However, due to the high temperature of the bath, the oxidation of glycerol was much faster than the nitration of glycerin thus preventing the formation of explosives.

Awarded Honorary Fellowship or membership

• Chemists' Club of New York, 1974
• Pharmaceutical Society of Japan, 1973
• Chemical Society of Japan, 2002
• Royal Society of Chemistry, UK, 1983
• Chairman Organic Division of the American Chemical Society, 1966–1967

Awards

Professor Stork received a number of awards and honors including the following:

• 1957 Award in Pure Chemistry of the American Chemical Society
• 1959 Guggenheim Foundation Fellow
• 1961 Baekeland Medal, North Jersey ACS
• 1962 Harrison Howe Award
• 1966 Edward Curtis Franklin Memorial Award, Stanford University
• 1967 ACS Award for Creative Work in Synthetic Organic Chemistry
• 1971 Synthetic Organic Chemical Manufacturers Association Gold Medal
• 1973 Nebraska Award
• 1978 Roussel Prize, Paris
• 1980 Nichols Medal, New York ACS, Arthur C. Cope Award, ACS
• 1982 Edgar Fahs Smith Award, Philadelphia ACS
• 1982 Willard Gibbs Medal, Chicago ACS
• 1982 National Academy of Sciences Award in Chemical Sciences
• 1982 National Medal of Science from Ronald Reagan; Linus Pauling Award
• 1985 Tetrahedron Prize
• 1986 Remsen Award, Maryland ACS
• 1986 Cliff S. Hamilton Award
• 1987 Monie A Ferst Award and Medal, Georgia Tech.
• 1991 Roger Adams Award
• 1992 George Kenner Award, Liverpool
• 1992 Robert Robinson Lectureship, University of Manchester
• 1992 Chemical Pioneer Award, American Institute of Chemists
• 1993 Welch Award in Chemistry, Robert A. Welch Foundation
• 1994 Allan R. Day Award, Philadelphia Organic Chemists Club
• 1995 Wolf Prize, Israel
• 2002 Sir Derek Barton Gold medal, Royal Society of Chemistry
• 2005 Herbert C. Brown Award, American Chemical Society

Stork also held honorary doctorates from Lawrence University, the University of Wisconsin–Madison, the University of Paris, the University of Rochester, and Columbia University.

The inaugural Gilbert Stork Lecture was held in his honor in 2014 at his alma mater, the University of Wisconsin-Madison. Gilbert Stork named lecture series are also held at other institutions, including Columbia University and the University of Pennsylvania, as a result of his endowments.

He was fêted for his sense of humor and colorful personality by historian of chemistry Jeffrey I. Seeman who published a collection of "Storkisms".

References

1. Wender, Paul A. (2017). "Gilbert Stork (1921–2017)". Nature. 551 (7682): 566. doi:10.1038/d41586-017-07527-8. PMID 29189811.
2. Nakamura, Eiichi; Winkler, Jeffrey D.; Aggarwal, Varinder K. (2018). "Gilbert Stork (1921–2017)". Angewandte Chemie International Edition. 57 (1): 36. doi:10.1002/anie.201711474. ISSN 1521-3773. PMID 29193592. S2CID 1109751.
3. ^ Hargittai, István; Hargittai, Magdolna (2003). More conversations with famous chemists ( ed.). London: Imperial College Press. pp. 109–119. ISBN 978-1-86094-336-2. Retrieved December 1, 2016.
4. Stork, Gilbert; Terrell, Ross; Szmuszkovicz, Jacob (April 1954). "A New Synthesis of 2-Alkyl and 2-Acyl Ketones". Journal of the American Chemical Society. 76 (7): 2029–2030. Bibcode:1954JAChS..76.2029S. doi:10.1021/ja01636a103.
5. ^ Seeman, Jeffrey I. (March 19, 2012). "Gilbert Stork: In His Own Words and in the Musings of His Friends". Angewandte Chemie International Edition. 51 (12): 3012–3023. doi:10.1002/anie.201200033. ISSN 1521-3773. PMID 22383434. S2CID 42348686.
6. ^ Stork, Gilbert (December 2011). "Chemical reminiscences" (PDF). Tetrahedron. 67 (51): 9754–9764. doi:10.1016/j.tet.2011.10.007. Archived from the original (PDF) on December 1, 2016. Retrieved December 1, 2016.
7. "C&EN's Top 75". Chemical and Engineering News. January 12, 1998. Retrieved December 1, 2016.
8. "UW Madison Chemistry Newsletter for February 17, 2014 Mon". University of Wisconsin. Archived from the original on December 1, 2016. Retrieved February 17, 2014.
9. Hoffman, Frances (1982). "Gilbert Stork: A Celebration of 35 Years in Research & Teaching". Aldrichimica Acta. 15: 1–10.
10. "Faculty Named to Learned Society". Columbia University Record. 20 (29). May 17, 1995. Retrieved December 1, 2016.
11. ^ "Emeritus Professor Gilbert Stork (Columbia University) was awarded an honorary member from the Chemical Society of Japan". Chemical Society of Japan. Retrieved December 1, 2016.
12. "Gilbert Stork". The Royal Society. Retrieved December 1, 2016.
13. "Ira Remsen Award". Maryland Section. November 14, 2018. Archived from the original on November 14, 2018. Retrieved November 14, 2018.
14. ^ Morris, Colin (January 10, 2005). "Chemistry Department Continues Award-Winning Legacy". Columbia News. Retrieved December 1, 2016.
15. Richardson, Lynda (May 20, 1993). "COMMENCEMENTS; Columbia Chief Stresses Role of Teacher". The New York Times. Retrieved December 1, 2016.
16. "Seminars". UW Madison Chemistry Newsletter. October 27, 2014. Archived from the original on December 1, 2016. Retrieved December 1, 2016.
17. "Named Lecture The Gilbert Stork Lecture". Columbia University. Archived from the original on June 20, 2016. Retrieved December 1, 2016.
18. "Gilbert Stork Lecture". University of Pennsylvania. Retrieved December 1, 2016.
19. Halford, Bethany (March 6, 2012). "Gilbert Stork on How Not to Dispose of a Steak". The Safety Zone. Retrieved March 6, 2012.

External links

• Finding aid to the Gilbert Stork papers at Columbia University Rare Book & Manuscript Library

• 1921 births
• 2017 deaths
• Belgian emigrants to the United States
• Belgian Jews
• American people of Belgian-Jewish descent
• American chemists
• Columbia University faculty
• Harvard University faculty
• Jewish American scientists
• Jewish chemists
• National Medal of Science laureates
• Foreign members of the Royal Society
• Belgian chemists
• University of Florida alumni
• University of Wisconsin–Madison alumni
• Wolf Prize in Chemistry laureates
• Members of the French Academy of Sciences
• Members of the United States National Academy of Sciences
• Organic chemists
• 21st-century American Jews