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ITGA3
Identifiers
Aliases	ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, integrin subunit alpha 3, JEB7
External IDs	OMIM: 605025; MGI: 96602; HomoloGene: 21129; GeneCards: ITGA3; OMA:ITGA3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.33 Start 50,055,968 bp End 50,090,481 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 59.01 cM Start 94,935,300 bp End 94,967,627 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in metanephric glomerulus right coronary artery upper lobe of left lung Descending thoracic aorta popliteal artery tibial arteries right lung right lobe of thyroid gland ascending aorta left lobe of thyroid gland Top expressed in genital tubercle lumbar spinal ganglion decidua tail of embryo corneal stroma yolk sac crypt of lieberkuhn of small intestine right lung lobe epithelium of lens ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein domain specific binding laminin binding collagen binding protease binding protein heterodimerization activity integrin binding fibronectin binding protein binding Cellular component extracellular exosome synapse integral component of membrane cell projection cell periphery cell junction growth cone membrane focal adhesion cell surface receptor complex synaptic membrane perinuclear region of cytoplasm excitatory synapse integrin complex basolateral plasma membrane filopodium membrane external side of plasma membrane integrin alpha3-beta1 complex plasma membrane growth cone filopodium Biological process positive regulation of neuron projection development extracellular matrix organization lung development mesodermal cell differentiation skin development maternal process involved in female pregnancy cell-matrix adhesion negative regulation of cell projection organization positive regulation of cell-substrate adhesion heart development dendritic spine maintenance positive regulation of gene expression nephron development memory integrin-mediated signaling pathway response to gonadotropin leukocyte migration renal filtration regulation of transforming growth factor beta receptor signaling pathway regulation of Wnt signaling pathway regulation of BMP signaling pathway negative regulation of Rho protein signal transduction exploration behavior positive regulation of epithelial cell migration neuron migration cell adhesion positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3675 16400 Ensembl ENSG00000005884 ENSMUSG00000001507 UniProt P26006 Q62470 RefSeq (mRNA) NM_002204 NM_005501 NM_013565 NM_001306071 NM_001306162 RefSeq (protein) NP_002195 NP_001293000 NP_001293091 NP_038593 Location (UCSC) Chr 17: 50.06 – 50.09 Mb Chr 11: 94.94 – 94.97 Mb PubMed search
Wikidata
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Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').

Interactions

CD49c has been shown to interact with:

• CD9
• FHL2,
• LGALS8, and
• TSPAN4.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000005884 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000001507 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (October 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol. 115 (1): 257–66. doi:10.1083/jcb.115.1.257. PMC 2289928. PMID 1655803.
6. Jones SD, van der Flier A, Sonnenberg A (September 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun. 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.
7. "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)".
8. Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (March 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. 6 (3): 252–7. doi:10.1093/molehr/6.3.252. PMID 10694273.
9. Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (February 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. 5 (2): 162–7. doi:10.1093/molehr/5.2.162. PMID 10065872.
10. Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
11. Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (July 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (13): 2385–97. doi:10.1242/jcs.113.13.2385. PMID 10852818.
12. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

Further reading

• Bosman FT (1993). "Integrins: cell adhesives and modulators of cell function". Histochem. J. 25 (7): 469–77. doi:10.1007/BF00159282. PMID 8407358. S2CID 19661102.
• Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain". Matrix Biol. 16 (4): 185–93. doi:10.1016/S0945-053X(97)90007-X. PMID 9402008.

External links

• CD49c+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• ITGA3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
• Human ITGA3 genome location and ITGA3 gene details page in the UCSC Genome Browser.

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