Misplaced Pages

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Irreversible agonist" – news · newspapers · books · scholar · JSTOR (January 2013) (Learn how and when to remove this message)

An irreversible agonist is a type of agonist that binds permanently to a receptor in such a manner that the receptor is permanently activated. It is distinct from a mere (reversible) agonist in that the association of an agonist to a receptor is reversible, whereas the binding of an irreversible agonist to a receptor is, at least in theory, irreversible. Oxymorphazone is an example of an irreversible agonist. In practice, the distinction may be more a matter of degree, in which the binding affinity of an irreversible agonist is some orders of magnitude greater than that of an agonist.

Examples

• Oxymorphazone
• Metaphit

See also

• Agonist
• Irreversible antagonist
• Irreversible enzyme inhibitor

References

1. Galetta S, Ling GS, Wolfin L, Pasternak GW (Sep 1982), "Receptor binding and analgesic properties of oxymorphazone", Life Sciences, 31 (12–13): 1389–92, doi:10.1016/0024-3205(82)90388-5, PMID 6183551

This pharmacology-related article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Receptor agonists
• Irreversible agonists
• Pharmacology stubs