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Lithium citrate

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Chemical used in psychiatric treatment
Lithium citrate
Names
Other names Trilithium citrate
trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.011.860 Edit this at Wikidata
EC Number
  • 213-045-8
PubChem CID
RTECS number
  • TZ8616000
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K
  • InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3Key: WJSIUCDMWSDDCE-DFZHHIFOAV
SMILES
  • ...O=C()CC(O)(C()=O)CC(=O)
Properties
Chemical formula Li3C6H5O7
Molar mass 209.923 g mol
Appearance Odorless white powder
Melting point decomposes at 105 °C (221 °F; 378 K)
Hazards
GHS labelling:
Pictograms GHS07: Exclamation mark
Signal word Warning
Hazard statements H302, H319
Precautionary statements P305+P351+P338
Flash point N/A
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Lithium citrate (Li3C6H5O7) is a lithium salt of citric acid that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder. There is extensive pharmacology of lithium, the active component of this salt.

Lithia water contains various lithium salts, including the citrate.

History

An early version of Coca-Cola available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup and lithia water. The soft drink 7Up was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. Lithium citrate was removed from 7Up in 1948 after the Food and Drug Administration banned its use in soda.

Lithium citrate is used as a mood stabilizer and is used to treat mania, hypomania, depression and bipolar disorder. It can be administered orally in the form of a syrup.

References

  1. Medication description
  2. "pms-Lithium Citrate - Uses, Side Effects, Interactions - MedBroadcast.com". medbroadcast.com. Retrieved 2017-08-15.
  3. "Medical use". Archived from the original on 2006-06-15. Retrieved 2006-07-29.
  4. "Lithium: medicine to control mood disorders such as mania and bipolar disorder". nhs.uk. 2020-08-17. Retrieved 2022-08-25.
  5. Gielen, Marcel; Edward R. T. Tiekink (2005). Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3. ISBN 0-470-86403-6.
  6. "Here's the Gross Thing That Happens when You Mix 7-Up with Lithium". Time, Inc. 2016-02-20. Retrieved 2024-12-11.
  7. ^ PubChem. "Lithium citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-09-08.


Mood stabilizers
Anticonvulsants
Atypical antipsychotics
Others
Lithium compounds (list)
Inorganic (list)
Organic (soaps)
Minerals
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