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mir-451
miR-451 microRNA secondary structure and sequence conservation
Identifiers
Symbol	mir-451
Rfam	RF00722
miRBase family	MIPF0000148
OMIM	612071
Other data
RNA type	microRNA
Domain(s)	Eukaryota; Vertebrata
PDB structures	PDBe

In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.

Applications

A proof-of-concept experiment has shown that miR-451, as well as mir-126 and mir-150, could be using in forensic science to distinguish between blood and saliva samples. This is made possible by different miRNA profiles of miRNAs in the different tissue types.

References

1. van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance". The International Journal of Biochemistry & Cell Biology. 42 (8): 1282–1290. doi:10.1016/j.biocel.2010.01.014. PMID 20083225.
2. ^ Courts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification". Journal of Forensic Sciences. 56 (6): 1464–1470. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476. S2CID 41948164.

Further reading

• Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC (2010). "Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis". Proc Natl Acad Sci U S A. 107 (34): 15163–15168. Bibcode:2010PNAS..10715163Y. doi:10.1073/pnas.1006432107. PMC 2930549. PMID 20699384.
• Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ (2010). "miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta". Genes Dev. 24 (15): 1620–1633. doi:10.1101/gad.1942110. PMC 2912560. PMID 20679398.
• Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L, Olson EN (2010). "Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta". Genes Dev. 24 (15): 1614–1619. doi:10.1101/gad.1942810. PMC 2912559. PMID 20679397.
• Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S (2010). "microRNA-451: A conditional switch controlling glioma cell proliferation and migration". Cell Cycle. 9 (14): 2742–2748. doi:10.4161/cc.9.14.12248. PMID 20647762.
• Svasti S, Masaki S, Penglong T, Abe Y, Winichagoon P, Fucharoen S, Umemura T (2010). "Expression of microRNA-451 in normal and thalassemic erythropoiesis". Ann Hematol. 89 (10): 953–958. doi:10.1007/s00277-010-0980-7. PMID 20461517. S2CID 35296680.
• Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE (2010). "MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells". Mol Cell. 37 (5): 620–632. doi:10.1016/j.molcel.2010.02.018. PMC 3125113. PMID 20227367.
• Bruchova-Votavova H, Yoon D, Prchal JT (2010). "miR-451 enhances erythroid differentiation in K562 cells". Leuk Lymphoma. 51 (4): 686–693. doi:10.3109/10428191003629362. PMID 20218812. S2CID 36579523.
• Tsuchiya S, Oku M, Imanaka Y, Kunimoto R, Okuno Y, Terasawa K, Sato F, Tsujimoto G, Shimizu K (2009). "MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells". Nucleic Acids Res. 37 (11): 3821–3827. doi:10.1093/nar/gkp255. PMC 2699527. PMID 19386621.
• Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, Zarate R, Diaz-Gonzalez JA, Ramirez N, Sola JJ, Jimenez P, Rodriguez J, Garcia-Foncillas J (2009). "microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells". Clin Cancer Res. 15 (7): 2281–2290. doi:10.1158/1078-0432.CCR-08-1818. PMID 19318487.
• Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ (2009). "miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2". Blood. 113 (8): 1794–1804. doi:10.1182/blood-2008-05-155812. PMC 2647672. PMID 18849488.
• Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, Amariglio N, Rechavi G, Givol D (2008). "MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells". Biochem Biophys Res Commun. 376 (1): 86–90. doi:10.1016/j.bbrc.2008.08.107. PMID 18765229.
• Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP (2008). "Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin". Mol Cancer Ther. 7 (7): 2152–2159. doi:10.1158/1535-7163.MCT-08-0021. PMID 18645025.
• Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM (2008). "Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells". Biochem Pharmacol. 76 (5): 582–588. doi:10.1016/j.bcp.2008.06.007. PMC 2628586. PMID 18619946.

External links

• Page for mir-451 microRNA precursor family at Rfam
• "MicroRNA MIR451 family (MIR451) Gene group". HUGO Gene Nomenclature Committee (HGNC).

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