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Monocyte distribution width (MDW) is a cytometry-based parameter that measures the range of variation of monocytes. If the parameter is available, it is reported as part of the standard complete blood count (CBC) with differential.

The parameter was FDA cleared as an early sepsis indicator for ER patients in 2019 for Beckman Coulter.

MDW serves as an indicator for early screening of sepsis in conjunction with CRP and PCT and for differentiating false positive blood cultures.

References

1. Bentahar, Ahmed (Sep 1, 2022). "What is Monocyte Distribution Width". Beckman Coulter.
2. "Beckman Coulter's Early Sepsis Indicator Receives 510(k) Clearance from the U.S. Food and Drug Administration". www.beckmancoulter.com. April 18, 2019.
3. "FDA Product Classification". FDA.
4. Jo, Sung Jin; Kim, Sei Won; Choi, Jung-Hyun; Choi, Seoung Pill; Lee, Jehoon; Lim, Jihyang (20 December 2022). "Monocyte distribution width (MDW) as a useful indicator for early screening of sepsis and discriminating false positive blood cultures". PLOS ONE. 17 (12): e0279374. Bibcode:2022PLoSO..1779374J. doi:10.1371/journal.pone.0279374. PMC 9767324. PMID 36538555.
5. Paxton, Anne (18 July 2023). "For sepsis Dx, MDW biomarker brought into the mix - CAP TODAY". CAP Today. Retrieved 16 April 2024.

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