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Nucleobindin 2

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(Redirected from NUCB2) Protein-coding gene in the species Homo sapiens

NUCB2
Identifiers
AliasesNUCB2, HEL-S-109, NEFA, nucleobindin 2
External IDsOMIM: 608020; MGI: 1858179; HomoloGene: 3676; GeneCards: NUCB2; OMA:NUCB2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for NUCB2Genomic location for NUCB2
Band11p15.1Start17,208,153 bp
End17,349,974 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for NUCB2Genomic location for NUCB2
Band7|7 F1Start116,103,604 bp
End116,139,819 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • tendon of biceps brachii

  • bronchial epithelial cell

  • olfactory zone of nasal mucosa

  • seminal vesicula

  • bone marrow cells

  • corpus epididymis

  • Achilles tendon

  • trabecular bone

  • body of pancreas
Top expressed in
  • seminal vesicula

  • lacrimal gland

  • salivary gland

  • submandibular gland

  • lobe of prostate

  • parotid gland

  • islet of Langerhans

  • saccule

  • olfactory epithelium

  • supraoptic nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4925

53322

Ensembl

ENSG00000070081

ENSMUSG00000030659

UniProt

P80303

P81117

RefSeq (mRNA)
NM_005013
NM_001330227
NM_001352661
NM_001352662
NM_001352663

NM_001352664
NM_001352665
NM_001352666
NM_001352667
NM_001352668
NM_001352669
NM_001352670
NM_001352671
NM_001352672

NM_001130479
NM_016773
NM_001360375

RefSeq (protein)
NP_001317156
NP_005004
NP_001339590
NP_001339591
NP_001339592

NP_001339593
NP_001339594
NP_001339595
NP_001339596
NP_001339597
NP_001339598
NP_001339599
NP_001339600
NP_001339601

NP_001123951
NP_001347304

Location (UCSC)Chr 11: 17.21 – 17.35 MbChr 7: 116.1 – 116.14 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Nucleobindin-2 is a protein that when found in humans is encoded by the NUCB2 gene.

Nucleobindin-2 is a calcium-binding EF-hand protein.

NUCB2 is protein precursor of nesfatin-1

In the study of the evolution of nervous systems, NUCB2 together with SMIM20 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.

Interactions

NUCB2 has been shown to interact with NDN.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000070081Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030659Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Barnikol-Watanabe S, Gross NA, Götz H, Henkel T, Karabinos A, Kratzin H, et al. (August 1994). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biological Chemistry Hoppe-Seyler. 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.
  6. ^ "Entrez Gene: NUCB2 nucleobindin 2".
  7. Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling". Molecular Biology and Evolution. 39 (4): msac051. doi:10.1093/molbev/msac051. PMC 9004410. PMID 35277960.
  8. Callier V (2022-06-03). "Brain-Signal Proteins Evolved Before Animals Did". Quanta Magazine. Retrieved 2022-06-03.
  9. Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". The Journal of Biological Chemistry. 275 (41): 31674–31681. doi:10.1074/jbc.M005103200. PMID 10915798.

Further reading

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