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Pinaverium bromide

Clinical data
ATC code	A03AX04 (WHO)
Identifiers
IUPAC name 4--4-heptanyl)ethoxy]ethyl]morpholin-4-ium bromide
CAS Number	53251-94-8
PubChem CID	40703
DrugBank	DBSALT001130
ChemSpider	37181
UNII	7SCF54H12J
CompTox Dashboard (EPA)	DTXSID90860655
Chemical and physical data
Formula	C26H41Br2NO4
Molar mass	591.425 g·mol
3D model (JSmol)	Interactive image
SMILES CC1(C2CCC(C1C2)CCOCC3(CCOCC3)Cc4cc(c(cc4Br)OC)OC)C.
InChI InChI=1S/C26H41BrNO4.BrH/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27;/h15,17,19,21-22H,5-14,16,18H2,1-4H3;1H/q+1;/p-1 Key:IKGXLCMLVINENI-UHFFFAOYSA-M
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Pinaverium bromide (INN) is a medication used for functional gastrointestinal disorders. It belongs to a drug group called antispasmodics and acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel. It is most effective when taken for a full course of treatment and is not designed for immediate symptom relief or sporadic, intermittent use.

Pinaverium bromide was first registered in 1975 by Solvay Pharmaceuticals (now a division of Abbott Laboratories), and marketed globally using the brand names Dicetel and Eldicet. Generic pinaverium is available in South Korea under a trade name of Disten and in Argentina as Nulite.

Indications

It is indicated for the treatment and relief of symptoms associated with irritable bowel syndrome (IBS) including abdominal pain, bowel disturbances and intestinal discomfort; and treatment of symptoms related to functional disorders of biliary tract.

References

1. "Trimebutine Maleate and Pinaverium Bromide for Irritable Bowel Syndrome: A Review of the Clinical Effectiveness, Safety and Guidelines [Internet].". CADTH Rapid Response Reports. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. November 2015. PMID 26985535.
2. "Drug/Drug Information: Disten Tablet". KMLE (in Korean). Archived from the original on 2018-09-20. Retrieved 2016-03-07.
3. "NULITE". Laboratorio Dominguez. Archived from the original on 2019-08-24. Retrieved 2017-07-03.
4. Abbott Laboratories (Feb 2012). Dicetel Product Insert/Information Malaysia.

• Calcium channel blockers
• Quaternary ammonium compounds
• Morpholines
• Drugs developed by AbbVie
• Phenol ethers
• Ethers
• Organobromides
• Methoxy compounds