Procollagen peptidase - Misplaced Pages

Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.

The enzyme is present in the skin of rats and humans.

References

"Procollagen peptidase". 7 October 2019.
Lapière CM, Lenaers A, Kohn LD (December 1971). "Procollagen peptidase: an enzyme excising the coordination peptides of procollagen". Proceedings of the National Academy of Sciences of the United States of America. 68 (12): 3054–8. Bibcode:1971PNAS...68.3054L. doi:10.1073/pnas.68.12.3054. PMC 389589. PMID 5289249.

External links

The MEROPS online database for peptidases and their inhibitors: Procollagen C-Peptidase:M12.005, Procollagen N-Peptidase:M12.301

External links

Procollagen+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Protein: scleroproteins

Extracellular
matrix

Collagen

Fibril forming

Other

FACIT: type IX
- COL9A1
- COL9A2
- COL9A3
type XII (COL12A1)
COL14A1
COL16A1
COL19A1
COL20A1
COL21A1
COL22A1

basement membrane: type IV
- COL4A1
- COL4A2
- COL4A3
- COL4A4
- COL4A5
- COL4A6

multiplexin: COL15A1
type XVIII
- COL18A1
- Endostatin

transmembrane: COL13A1
COL17A1
COL23A1
COL25A1

other: type VI
- COL6A1
- COL6A2
- COL6A3
- COL6A5
type VII (COL7A1)
type VIII
- COL8A1
- COL8A2
type X (COL10A1)
type XI
- COL11A1
- COL11A2
COL27A1
COL28A1

Enzymes

Laminin

alpha
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
beta
- LAMB1
- LAMB2
- LAMB3
- LAMB4
gamma
- LAMC1
- LAMC2
- LAMC3

Other

See also: diseases

v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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