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60S ribosomal protein L21

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(Redirected from RPL21) Protein found in humans
RPL21
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5AJ0, 3J7R, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC

Identifiers
AliasesRPL21, HYPT12, L21, ribosomal protein L21
External IDsOMIM: 603636; MGI: 1278340; HomoloGene: 128048; GeneCards: RPL21; OMA:RPL21 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)
Chromosome 13 (human)Genomic location for RPL21Genomic location for RPL21
Band13q12.2Start27,251,362 bp
End27,256,691 bp
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for RPL21Genomic location for RPL21
Band5|5 G3Start146,769,700 bp
End146,773,842 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ganglionic eminence

  • primary visual cortex

  • epithelium of colon

  • endometrium

  • lymph node

  • ventricular zone

  • white blood cell

  • monocyte

  • superior frontal gyrus
Top expressed in
  • ovary

  • urinary bladder

  • ventricular zone

  • ganglionic eminence

  • lens

  • zone of skin

  • uterus

  • adrenal gland

  • esophagus

  • ileum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6144

19933

Ensembl

ENSG00000122026

ENSMUSG00000041453

UniProt

P46778

O09167
Q9CQM8

RefSeq (mRNA)

NM_000982

NM_019647

RefSeq (protein)

NP_000973

NP_062621

Location (UCSC)Chr 13: 27.25 – 27.26 MbChr 5: 146.77 – 146.77 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Clinical relevance

Mutations in the RPL21 gene result in Hypotrichosis simplex of the scalp.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000122026Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041453Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nakamichi NN, Kao FT, Wasmuth J, Roufa DJ (Jul 1986). "Ribosomal protein gene sequences map to human chromosomes 5, 8, and 17". Somat Cell Mol Genet. 12 (3): 225–36. doi:10.1007/BF01570781. PMID 3459254. S2CID 20534231.
  6. Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
  7. ^ "Entrez Gene: RPL21 ribosomal protein L21".
  8. Zhou C, Zang D, Jin Y, et al. (March 2011). "Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex". Human Mutation. 32 (7): 710–4. doi:10.1002/humu.21503. PMID 21412954. S2CID 3715445.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: P46778 (60S ribosomal protein L21) at the PDBe-KB.


Protein biosynthesis: translation (bacterial, archaeal, eukaryotic)
Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/Mitochondrial
Archaeal/Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
Ribosomal RNA / ribosome subunits
Archaea
(70S)
Large (50S):
Small (30S):
Bacteria
(70S)
Large (50S):
Small (30S):
Eukaryotes
Cytoplasmic (80S)Large (60S):
Small (40S):
Mitochondrial (55S)Large (28S):
Small (39S):
Chloroplast (70S)Large (50S):
Small (30S):
Ribosomal proteins(See article table)
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