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Tinyatoxin

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Tinyatoxin
Names
Preferred IUPAC name benzodioxol-5-yl]methyl (4-hydroxyphenyl)acetate
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.165.094 Edit this at Wikidata
MeSH tinyatoxin
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C36H38O8/c1-21(2)34-17-23(4)36-28(32(34)42-35(43-34,44-36)19-25-8-6-5-7-9-25)15-26(18-33(40)29(36)14-22(3)31(33)39)20-41-30(38)16-24-10-12-27(37)13-11-24/h5-15,23,28-29,32,37,40H,1,16-20H2,2-4H3/t23-,28+,29-,32-,33-,34-,35-,36-/m1/s1Key: WWZMXEIBZCEIFB-ACAXUWNGSA-N
SMILES
  • C1C2(341(5C=C(C(=O)5(CC(=C4)COC(=O)Cc6ccc(cc6)O)O)C)O(O3)(O2)Cc7ccccc7)C(=C)C
Properties
Chemical formula C36H38O8
Molar mass 598.692 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkverify (what is  ?) Infobox references
Chemical compound
Tinyatoxin
HeatAbove peak
Scoville scale5,300,000,000 SHU

Tinyatoxin (TTX or TTN) is an analog of the neurotoxin resiniferatoxin. It occurs naturally in Euphorbia poissonii.

It is a neurotoxin that acts via full agonism of the vanilloid receptors of sensory nerves. Tinyatoxin has a potential for pharmaceutical uses similar to uses of capsaicin. Tinyatoxin is about one third as strong as resiniferatoxin but is still an ultrapotent analogue of capsaicin, with a heat intensity estimate of 300 to 350 times that of capsaicin.

References

  1. Euphorbia poissonii in BoDD – Botanical Dermatology Database
  2. Szallasi, A. & Blumberg, P.M. (1991). "Characterization of vanilloid receptors in the dorsal horn of pig spinal cord". Brain Res. 547 (2): 335–338. doi:10.1016/0006-8993(91)90982-2. PMID 1884211. S2CID 25052101.


TRP channel modulators
TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers
See also: Receptor/signaling modulatorsIon channel modulators


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