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Azosemide: Difference between revisions

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{{Short description|Chemical compound}}
{{Drugbox {{Drugbox
| Verifiedfields = changed | Verifiedfields = changed
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| verifiedrevid = 458285216 | verifiedrevid = 458285216
| IUPAC_name = 2-chloro-5-(2H-tetrazol-5-yl)-4-benzenesulfonamide | IUPAC_name = 2-chloro-5-(2H-tetrazol-5-yl)-4-benzenesulfonamide
| image = Azosemid.svg | image = Azosemide.svg
| alt = Structural formula of azosemide | alt = Structural formula of azosemide
| width = 140 | width = 140
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2186 | ChemSpiderID = 2186
| InChI = 1/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)
| InChIKey = HMEDEBAJARCKCT-UHFFFAOYAX
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19) | StdInChI = 1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)
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<!--Chemical data--> <!--Chemical data-->
| C=12 | H=11 | Cl=1 | N=6 | O=2 | S=2 | C=12 | H=11 | Cl=1 | N=6 | O=2 | S=2
⚫ | smiles = O=S(=O)(N)c2c(Cl)cc(c(c1nnn1)c2)NCc3sccc3
| molecular_weight = 370.84 g/mol
⚫ | smiles = O=S(=O)(N)c2c(Cl)cc(c(c1nnnn1)c2)NCc3sccc3
}} }}


'''Azosemide''' is a high-ceiling ] agent that was brought to market in 1981 by ].<ref>{{ cite book| vauthors = Sittig M |title=Pharmaceutical Manufacturing Encyclopedia |volume=1 |publisher=Noyes Publications |year=1988 |page=122 |isbn= 978-0-8155-1144-1 |url=http://files.rushim.ru/books/lekarstva/pharmaceutical-encyclopedia.pdf |url-status=dead |archive-url= https://web.archive.org/web/20071023210611/http://files.rushim.ru/books/lekarstva/pharmaceutical-encyclopedia.pdf |archivedate=2007-10-23 }}</ref><ref>{{cite book | vauthors = Bormann D | chapter = Diuretics | veditors = Hess HJ | title = Annual Reports in Medicinal Chemistry | date = January 1980 | volume = 15 | pages = 100–105 (101) | publisher = Academic Press | isbn = 978-0-08-058359-4 }}</ref> As of 2015 it was available as a generic in some Asian countries.<ref>{{cite web | work = Drugs.com | url = https://www.drugs.com/international/azosemide.html | title = International listings for azosemide | access-date = 23 July 2015 }}</ref>
'''Azosemide''' is a high-ceiling ] agent.



Azosemide has been found as an adulterant in ].<ref>{{cite web |title=Drug Checking Report 2011 |url=https://energycontrol.org/files/analisis/Annual_Drug_Checking_Report_Energy_Control_2011.pdf |website=Energy Control |access-date=20 January 2022 |archive-date=20 January 2022 |archive-url=https://web.archive.org/web/20220120232735/https://energycontrol.org/files/analisis/Annual_Drug_Checking_Report_Energy_Control_2011.pdf |url-status=live }}</ref>
==References== ==References==
{{reflist}}
Popelak, A.; Lerch, A.; Stach, K.; Roesch, E.; Hardebeck, K.; German Offen., 1970, 815922; Chem. Abstr. 1970, 73, 45519.


] ]
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] ]


{{Diuretics}}

{{cardiovascular-drug-stub}} {{cardiovascular-drug-stub}}

Latest revision as of 07:07, 24 December 2024

Chemical compound Pharmaceutical compound
Azosemide
Structural formula of azosemide
Space-filling model of the azosemide molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
  • none
Identifiers
IUPAC name
  • 2-chloro-5-(2H-tetrazol-5-yl)-4-benzenesulfonamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.044.121 Edit this at Wikidata
Chemical and physical data
FormulaC12H11ClN6O2S2
Molar mass370.83 g·mol
3D model (JSmol)
SMILES
  • O=S(=O)(N)c2c(Cl)cc(c(c1nnn1)c2)NCc3sccc3
InChI
  • InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)
  • Key:HMEDEBAJARCKCT-UHFFFAOYSA-N
  (what is this?)  (verify)

Azosemide is a high-ceiling loop diuretic agent that was brought to market in 1981 by Boehringer Mannheim. As of 2015 it was available as a generic in some Asian countries.


Azosemide has been found as an adulterant in ketamine.

References

  1. Sittig M (1988). Pharmaceutical Manufacturing Encyclopedia (PDF). Vol. 1. Noyes Publications. p. 122. ISBN 978-0-8155-1144-1. Archived from the original (PDF) on 2007-10-23.
  2. Bormann D (January 1980). "Diuretics". In Hess HJ (ed.). Annual Reports in Medicinal Chemistry. Vol. 15. Academic Press. pp. 100–105 (101). ISBN 978-0-08-058359-4.
  3. "International listings for azosemide". Drugs.com. Retrieved 23 July 2015.
  4. "Drug Checking Report 2011" (PDF). Energy Control. Archived (PDF) from the original on 20 January 2022. Retrieved 20 January 2022.
Diuretics (C03)
Sulfonamides
(and etacrynic acid)
CA inhibitors (at PT)
Loop (Na-K-Cl at AL)
Thiazides (Na-Cl at DCT,
Calcium-sparing)
Thiazide-likes (primarily DCT)
Potassium-sparing (at CD)
ESC blockers
Aldosterone antagonists
Osmotic diuretics (PT, DL)
Vasopressin receptor inhibitors
(DCT and CD)
Other
Combination products
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