Misplaced Pages

Simeticone: Difference between revisions

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively← Previous editContent deleted Content addedVisualWikitext
Revision as of 05:05, 22 March 2011 editKiAnCaFleur (talk | contribs)35 editsm Chemical action and pharmaceutical effects: Quoted source on side effects.← Previous edit Latest revision as of 01:58, 11 October 2024 edit undoMuhammad Anas Sidik (talk | contribs)295 editsNo edit summaryTags: Mobile edit Mobile web edit 
(303 intermediate revisions by more than 100 users not shown)
Line 1: Line 1:
{{short description|Anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas}}
{{drugbox
{{Missing information|the history of simeticone|date=September 2021}}
| verifiedrevid = 407521151
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 417768970
| IUPAC_name = Poly(dimethylsiloxane), silicon dioxide | IUPAC_name = Poly(dimethylsiloxane), silicon dioxide
| image = Simethicone structure.svg | image = Simethicone structure.svg
<!--Clinical data -->
| tradename = Infacol, Wind-eze, WindSetlers, many others
|USAN = simethicone<ref>{{cite web|title=Simethicone names|url=https://www.drugs.com/international/simethicone.html|publisher=Drugs.com|access-date=27 August 2017}}</ref>
| Drugs.com = {{drugs.com|monograph|simethicone}}
| pregnancy_category = C
| legal_US = OTC
| routes_of_administration = Oral
<!--Pharmacokinetic data -->
| bioavailability = None
| protein_bound = 0%
| metabolism = Not metabolized
| elimination_half-life = N/A
| excretion = Feces
<!--Identifiers -->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 8050-81-5 | CAS_number = 8050-81-5
| ATC_prefix = A03 | ATC_prefix = A03
| ATC_suffix = AX13 | ATC_suffix = AX13
| PubChem = 6433516 | PubChem = 6433516
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| DrugBank =
| ChemSpiderID = None
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB09512
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1200838
<!--Chemical data -->
| chemical_formula = (C<sub>2</sub>H<sub>6</sub>OSi)<sub>n</sub> · (SiO<sub>2</sub>)<sub>m</sub> | chemical_formula = (C<sub>2</sub>H<sub>6</sub>OSi)<sub>n</sub> · (SiO<sub>2</sub>)<sub>m</sub>
| molecular_weight = variable | molecular_weight = Variable
| melting_point =
| bioavailability = not absorbed from the gut
| protein_bound = N/A
| metabolism = N/A
| elimination_half-life = N/A
| excretion = N/A
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_UK =
| legal_US = OTC
| routes_of_administration = Oral
}} }}
'''Simethicone''' is an ] ] used to reduce ], discomfort and pain caused by excess gas in the stomach or intestinal tract. It is a mixture of ] and ]. '''Simeticone''' (]), also known as '''simethicone''' (]), is an ] used to reduce ], discomfort or pain caused by excessive gas.


==Medical uses==
==Chemical action and pharmaceutical effects==
]
Simeticone is used to relieve the symptoms of excessive gas in the ], namely bloating, burping, and flatulence.<ref name=USOTClabel>{{cite web|title=Simethicone tablet|url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d93ff75d-9cdb-476c-bb65-eabeefb91a34|publisher=NIH DailyMed|access-date=27 August 2017|date=April 2016}}</ref><ref>{{cite web|title=Simeticone|url=https://www.nhs.uk/medicines/simeticone/|publisher=]|language=en|date=10 October 2019|access-date=30 January 2020}}</ref> While there is a lack of conclusive evidence that simeticone is effective for this use,⁣<ref>{{cite web| vauthors = Modi R, Clearfield HR, Levitt M | title=Belching, Bloating and Flatulence|url=http://patients.gi.org/topics/belching-bloating-and-flatulence/|publisher=American College of Gastroenterology|language=en|date=July 2013}}</ref><ref name="drugs.com">{{Cite web | url = https://www.drugs.com/monograph/simethicone.html | title = Simethicone | publisher = ] | quote = Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress}}</ref>{{Failed verification|date=January 2020|reason=Flatulence/bloating and IPPUAD are separate sections in source}} studies have shown that it can relieve symptoms of ]<ref>{{cite journal | vauthors = Holtmann G, Gschossmann J, Mayr P, Talley NJ | title = A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia | journal = Alimentary Pharmacology & Therapeutics | volume = 16 | issue = 9 | pages = 1641–8 | date = September 2002 | pmid = 12197843 | doi = 10.1046/j.1365-2036.2002.01322.x | publisher = Wiley | s2cid = 23286985 | doi-access = }}</ref> and ].<ref>{{cite journal | vauthors = Burta O, Iacobescu C, Mateescu RB, Nicolaie T, Tiuca N, Pop CS | title = Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study | journal = Translational Gastroenterology and Hepatology | volume = 3 | issue = 72 | pages = 72 | date = 25 September 2018 | pmid = 30511026 | pmc = 6256934 | doi = 10.21037/tgh.2018.09.11 | publisher = AME Publications | doi-access = free }}</ref>


It has not been fully established that simeticone is useful to treat ] in babies,<ref>{{cite journal | vauthors = Biagioli E, Tarasco V, Lingua C, Moja L, Savino F | title = Pain-relieving agents for infantile colic | journal = The Cochrane Database of Systematic Reviews | volume = 2016 | pages = CD009999 | date = September 2016 | issue = 9 | pmid = 27631535 | pmc = 6457752 | doi = 10.1002/14651858.CD009999.pub2 }}</ref> and it is not recommended for this purpose.<ref name="drugs.com"/> A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.<ref>{{cite journal | vauthors = Goldman M, Beaumont T | title = A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents | journal = British Journal of Nursing | volume = 26 | issue = 5 Suppl 1 | pages = S3–S10 | date = March 2017 | pmid = 28350192 | doi = 10.12968/bjon.2017.26.Sup5.S3 | s2cid = 32885530 }}</ref>
Simethicone is an anti-foaming agent that decreases the ] of gas ]s, causing them to combine into larger bubbles in the ] that can be passed more easily by ]. Simethicone does not reduce or prevent the formation of gas in the ], rather, it increases the rate at which it exits the body.<ref>{{Cite web | last =Norton | first =William | title =Controlling Intestinal Gas | date =2005-01-09 | url =http://www.iffgd.org/store/viewproduct/155 | accessdate =2007-07-31}}</ref> However, simethicone can relieve pain caused by gas in the intestines by decreasing foaming which then allows for passing of ]. Simethicone is not absorbed by the body into the bloodstream, and is therefore considered relatively safe. National Institutes of Health (NIH)<ref>PubMed Health, produced by National Center for Biotechnology, a division of the National Library of Medicine at the National Institutes of Health; see http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000747/</ref> reports there are usually no side effects when Simethicone is taken as directed. While sold as a treatment for ], randomised controlled trials have not borne this claim out.<ref></ref><ref></ref>


Simeticone can also be used for suspected ] ] in infants.<ref>{{cite journal | vauthors = Voepel-Lewis TD, Malviya S, Burke C, D'Agostino R, Hadden SM, Siewert M, Tait AR | title = Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants | journal = Journal of Clinical Anesthesia | volume = 10 | issue = 2 | pages = 91–94 | date = March 1998 | pmid = 9524891 | doi = 10.1016/S0952-8180(97)00249-3 }}</ref>
Simethicone solutions of differing concentration also have industrial applications for reducing foaming in certain chemical processes.


==Dosage== ==Side effects==
Simeticone does not have any serious side effects.<ref name=":0" /> Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.<ref>{{cite web |title= Simethicone Side Effects in Detail |url=https://www.drugs.com/sfx/simethicone-side-effects.html| work = Drugs.com |access-date=27 August 2017}}</ref>
]
Simethicone comes in many different oral forms, which have differing usual ]. Though there are standard dosages for adults and teens, dosages for children should be determined by a doctor.


==Pharmacology==
* Capsules or tablets:
Simeticone is a non-systemic ] which decreases the surface tension of gas bubbles in the GI tract.<ref name=":0">{{Cite journal| vauthors = Ingold CJ, Akhondi H |date=January 2021|title=Simethicone|url=https://www.ncbi.nlm.nih.gov/books/NBK555997/|journal=StatPearls .|pmid=32310457 }}</ref> This allows gas bubbles to leave the GI tract as ] or ].<ref name=":0" /> Simeticone does not reduce or prevent the formation of gas.<ref>{{cite web|title=Treatment of Gas|url=https://iffgd.org/symptoms-causes/intestinal-gas/treatment.html|publisher=International Foundation for Functional Gastrointestinal Disorders|language=en-gb|date=4 September 2015}}</ref> Its effectiveness has been shown in several ] studies.<ref>{{cite journal | vauthors = Brecević L, Bosan-Kilibarda I, Strajnar F | title = Mechanism of antifoaming action of simethicone | journal = Journal of Applied Toxicology | volume = 14 | issue = 3 | pages = 207–11 | date = May 1994 | pmid = 8083482 | doi = 10.1002/jat.2550140311 | url = https://www.researchgate.net/publication/15114732 | access-date = 30 January 2020 | publisher = Wiley | s2cid = 7453218 }}</ref><ref>{{cite journal | vauthors = Dittrich M, Miederer SE, Havertz B, Krastev R | title = Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro |journal= Journal für Gastroenterologische und Hepatologische Erkrankungen. |trans-title=Defoaming and antifoaming action of simethicone in vitro | language = German | date = 12 May 2010 | volume = 8 | issue = 3 | pages = 19–25 | url = https://www.kup.at/kup/pdf/9192.pdf | publisher=Krause & Pachernegg }}</ref>
:: Adults and teenagers: 60 to 125 milligrams (mg) four times a day, or 180mg twice a day, after meals and at bedtime. No more than 500 mg should be taken in twenty-four hours.


==Chemistry==
* Chewable tablets:
Simeticone is a mixture of ] and ].<ref name="merck-dimethicone"> {{cite encyclopedia |author-link= |veditors = O'Neil MJ |encyclopedia=The Merck Index |title=Dimethicone |edition=14th |year=2006 |publisher=Merck |location=Whitehouse Station, NJ |page=545 }} </ref>
::Adults and teenagers: 40 to 125 mg four times a day, after meals and at bedtime or the dose may be 150 mg three times a day, after meals. No more than 500 mg should be taken in twenty-four hours.


==Names==
* Suspension:
The INN name is "simeticone", which was added to the INN recommended list in 1999.<ref name=INN>{{cite journal|title=Recommended INN List 42|journal=WHO Drug Information|date=1999|volume=13|issue=3|url=https://www.who.int/medicines/publications/druginformation/innlists/RL42.pdf?ua=1|page=202}}</ref>
::Adults and teenagers: 40 to 95 mg four times a day, after meals and at bedtime. No more than 500 mg should be taken in twenty-four hours.


Simeticone is marketed under many brand names and in many ]; it is also marketed as a veterinary drug.<ref name=brands>{{cite web|title=Simeticone international brands|url=https://www.drugs.com/international/simeticone.html|publisher=Drugs.com|access-date=27 August 2017}}</ref>
* Dissolving membrane:
::A thin dissolving membrane dose that is placed on the tongue and dissolves with ]. No more than 500 mg should be taken in twenty-four hours.


{{collapse top|Brands}}
== Availability ==
Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Polysilane Junior, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.<ref name=brands/>
'''Simethicone''' is generally available over the counter under many trade names in varying dosage sizes and combinations with other drugs, including:


It is also marketed as a ]:<ref name=brands/>
{{col-begin}}
* with ] as Kestomatine
{{col-2}}
* with ] or ] salts and in some cases both, as Alamag Plus, Almacone, Alposim, Aluphagel, Alutop, Amico-L Andursil, Axcel Eviline, Boots Wind Relief, Di-Gel, Diovol Plus, Diovol Plus AF, Gas Ban DS, Hydrosil, Iosopan Plus, Kremil, Kremil-S, Maalox Plus, Magasida, Mi-Acid, Mygel, Mylagen, Mylanta, Polysilane, Polysilane Delalande, Rumibex and Trial AG
* Aero-Red (Spain)
* with ] as Avarin, Meteospasmyl, Nady-Spasmyl
* Air-X (Thailand)
* with ] as Bario Dif
* Antiflat<ref> {{de icon}}</ref><ref> {{de icon}}</ref> (Austria)
* with ] as Gastop
* Baby's Own Infant Drops
* with ] as Flamints, Gaseoflatex Plus, Malugel, Titralac Plus
* Cuplaton (])
* with ] as Carbosylane, Clingest, Finigax. Flatuna
* Deflatine
* with ] as Rogastril Plus
* De-Gas
* with ] as Flatoril
* Disflatyl
* with ] as Cloact, Colicspam, Colimix, Colispas, Coliza-D, Cyclopam, Fri-Spas, Meftal Spas, Respas, Simcomine, Spasact, Spasmindon DPS
* Espumisan (Bulgaria, Romania)
* with ] as Bigetric, Dom Simecon, Doprokin-S, Glomoti, Moperidona AF, Mutecium, Praxis
* Flatulex
* with ] as Altacide and Talsil Forte
* Factor AG 200 (Argentina)
* with ] as Aero-Sim Compuesto, Asestor, Factor AG, Sedotropina Flat
* GasAid
* with ] as Dinolak
* Gascon (Taiwan)
* with ] as Jaydess
* Gas-Med
* with ] as Eldoper Plus, Imodium Duo, Imolopesim, Loperamide HCl/Dimeticon, Loperuma, Lositala, Losiwuto, Regulane AF, Stoperan Plus, Toban F Plus
* Gas Relief
* with ] as Aci Basic, Aci-Tip, Acicone-S, Acid-Farvet, Acifin, Amalset, Antiax, Asidrat, Assis, Avicid, Banacid-s, Buenox, Cremalon, Curecid, Digax, Digeril, Endcid, Gaseovet MS, Gastrine, Gastrogel, Gastroral, Gastrorapid, Magacid, Magal-D, Magalat, Magaldrato+Simeticona, Magaldrax, Maganta Plus, Magsilon, Marlox Plus, Megacil Plus, Megalrat Plus, Minicidez, Miopan Plus, Novelta, Oxecone-MS, Riopan Plus, Rolac Plus, Sedo Mag, Simagal, Simelgat Plus, Taimacon, Zymcon
* Gasvan (Serbia)
* with ] as Anaflat Compuesto, Di-Aero OM, Digespar, Factorine, Pangastren
* Gas-X
* with ] as M-Pride-MPS, Moxar, Moza MPS
* Gazim X (Israel)
* with ] as Anaflat Enzimático, Digenil, Digesflat, Enzym Lefax, Enzymet, Enzymin, fermento duodenal, Finigax Indigestion, Flaton, Flazymec, Gasflat, Gaszym, Gesdyp, Hazmolin, Komflat, MeteoZym, Pankreoflat, Tripanzym
* Genasyme
* with ] as Espasmo Siligas
* Imodium Multi-Symptom Relief (formerly Imodium Advanced)
* with ] as Alevian Duo, Pladuet, Planex
* Imogas
* with ] as Cadinol, Gasorbol Gotas
* Imonogas
* with ] as Meteoxane
* ]
* with ] as Eumotil-S, Eumotrix Plus, Libertrim SDP, Libertrim SII, Muvett S
* Infacon
* with ] as Hidribet.
* Kremil-S
* Kupla Stop (Finland)
{{col-2}}
* Lefax (Germany)
* Little Tummys
* (Brazil and Mexico)
* ] Anti-Gas
* Maalox Max
* Mag77
* Metsil (Turkey)
* Minifom (Norway, Sweden)
* My Baby Gas Relief Drops
* ] Gas
* Mylanta Gas Relief
* Mylicon Drops
* Mylicongas (Italy)
* Ovol
* Phazyme
* Rolaids
* SAB Simplex
* Siloxogene (India)
* Simeco
* Telament (South Africa)
* Triaerom (Peru)
* WindEze (UK)
* Flatin (HU)
* Refalgin (IT)
{{col-end}}


It is also marketed as a veterinary drug under the brands Birp and Methysilox.
== Other uses ==
{{collapse bottom}}
Simethicone is used in some ]s when foaming is unwanted.

Simethicone is also used in the fermentation process to reduce the shearing of proteins by agitation.


== References == == References ==
{{Reflist}} {{Reflist|30em}}

==External links==
* {{cite web | title=Jackson Gastroenterology - Patient Education - Simethicone | url=http://www.gicare.com/pated/simethicone.htm| accessdate=July 30, 2005 }}
* {{cite web | title=Medline Plus - Simethicone | url=http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682683.html | accessdate=April 16, 2007 |archiveurl = http://web.archive.org/web/20070219022008/http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682683.html <!-- Bot retrieved archive --> |archivedate = February 19, 2007}}


{{Drugs for functional gastrointestinal disorders}} {{Drugs for functional gastrointestinal disorders}}
Line 122: Line 100:
] ]
] ]
] ]
] ]
]
] ]

]
]
]
]
]
]

Latest revision as of 01:58, 11 October 2024

Anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas
This article is missing information about the history of simeticone. Please expand the article to include this information. Further details may exist on the talk page. (September 2021)
Pharmaceutical compound
Simeticone
Clinical data
Trade namesInfacol, Wind-eze, WindSetlers, many others
Other namessimethicone (USAN US)
AHFS/Drugs.comMonograph
Pregnancy
category
  • C
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityNone
Protein binding0%
MetabolismNot metabolized
Elimination half-lifeN/A
ExcretionFeces
Identifiers
IUPAC name
  • Poly(dimethylsiloxane), silicon dioxide
CAS Number
PubChem CID
DrugBank
ChemSpider
  • None
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.107.016 Edit this at Wikidata
Chemical and physical data
Formula(C2H6OSi)n · (SiO2)m
Molar massVariable
  (what is this?)  (verify)

Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.

Medical uses

Simethicone tablets

Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence. While there is a lack of conclusive evidence that simeticone is effective for this use,⁣ studies have shown that it can relieve symptoms of functional dyspepsia and functional bloating.

It has not been fully established that simeticone is useful to treat colic in babies, and it is not recommended for this purpose. A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.

Simeticone can also be used for suspected postoperative abdominal discomfort in infants.

Side effects

Simeticone does not have any serious side effects. Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.

Pharmacology

Simeticone is a non-systemic surfactant which decreases the surface tension of gas bubbles in the GI tract. This allows gas bubbles to leave the GI tract as flatulence or belching. Simeticone does not reduce or prevent the formation of gas. Its effectiveness has been shown in several in vitro studies.

Chemistry

Simeticone is a mixture of dimethicone and silicon dioxide.

Names

The INN name is "simeticone", which was added to the INN recommended list in 1999.

Simeticone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.

Brands

Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Polysilane Junior, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.

It is also marketed as a combination drug:

  • with algeldrate as Kestomatine
  • with aluminium or magnesium salts and in some cases both, as Alamag Plus, Almacone, Alposim, Aluphagel, Alutop, Amico-L Andursil, Axcel Eviline, Boots Wind Relief, Di-Gel, Diovol Plus, Diovol Plus AF, Gas Ban DS, Hydrosil, Iosopan Plus, Kremil, Kremil-S, Maalox Plus, Magasida, Mi-Acid, Mygel, Mylagen, Mylanta, Polysilane, Polysilane Delalande, Rumibex and Trial AG
  • with alverine as Avarin, Meteospasmyl, Nady-Spasmyl
  • with barium sulfate as Bario Dif
  • with bismuth as Gastop
  • with calcium carbonate as Flamints, Gaseoflatex Plus, Malugel, Titralac Plus
  • with activated charcoal as Carbosylane, Clingest, Finigax. Flatuna
  • with cinitapride as Rogastril Plus
  • with clebopride as Flatoril
  • with dicycloverine as Cloact, Colicspam, Colimix, Colispas, Coliza-D, Cyclopam, Fri-Spas, Meftal Spas, Respas, Simcomine, Spasact, Spasmindon DPS
  • with domperidone as Bigetric, Dom Simecon, Doprokin-S, Glomoti, Moperidona AF, Mutecium, Praxis
  • with hydrotalcite as Altacide and Talsil Forte
  • with homatropine as Aero-Sim Compuesto, Asestor, Factor AG, Sedotropina Flat
  • with lactulose as Dinolak
  • with levonorgestrel as Jaydess
  • with loperamide as Eldoper Plus, Imodium Duo, Imolopesim, Loperamide HCl/Dimeticon, Loperuma, Lositala, Losiwuto, Regulane AF, Stoperan Plus, Toban F Plus
  • with magaldrate as Aci Basic, Aci-Tip, Acicone-S, Acid-Farvet, Acifin, Amalset, Antiax, Asidrat, Assis, Avicid, Banacid-s, Buenox, Cremalon, Curecid, Digax, Digeril, Endcid, Gaseovet MS, Gastrine, Gastrogel, Gastroral, Gastrorapid, Magacid, Magal-D, Magalat, Magaldrato+Simeticona, Magaldrax, Maganta Plus, Magsilon, Marlox Plus, Megacil Plus, Megalrat Plus, Minicidez, Miopan Plus, Novelta, Oxecone-MS, Riopan Plus, Rolac Plus, Sedo Mag, Simagal, Simelgat Plus, Taimacon, Zymcon
  • with metoclopramide as Anaflat Compuesto, Di-Aero OM, Digespar, Factorine, Pangastren
  • with mosapride as M-Pride-MPS, Moxar, Moza MPS
  • with pancreatin as Anaflat Enzimático, Digenil, Digesflat, Enzym Lefax, Enzymet, Enzymin, fermento duodenal, Finigax Indigestion, Flaton, Flazymec, Gasflat, Gaszym, Gesdyp, Hazmolin, Komflat, MeteoZym, Pankreoflat, Tripanzym
  • with papaverine as Espasmo Siligas
  • with pinaverium as Alevian Duo, Pladuet, Planex
  • with pipenzolate bromide as Cadinol, Gasorbol Gotas
  • with phloroglucinol as Meteoxane
  • with trimebutine as Eumotil-S, Eumotrix Plus, Libertrim SDP, Libertrim SII, Muvett S
  • with urea as Hidribet.

It is also marketed as a veterinary drug under the brands Birp and Methysilox.

References

  1. "Simethicone names". Drugs.com. Retrieved 27 August 2017.
  2. "Simethicone tablet". NIH DailyMed. April 2016. Retrieved 27 August 2017.
  3. "Simeticone". NHS. 10 October 2019. Retrieved 30 January 2020.
  4. Modi R, Clearfield HR, Levitt M (July 2013). "Belching, Bloating and Flatulence". American College of Gastroenterology.
  5. ^ "Simethicone". drugs.com. Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress
  6. Holtmann G, Gschossmann J, Mayr P, Talley NJ (September 2002). "A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". Alimentary Pharmacology & Therapeutics. 16 (9). Wiley: 1641–8. doi:10.1046/j.1365-2036.2002.01322.x. PMID 12197843. S2CID 23286985.
  7. Burta O, Iacobescu C, Mateescu RB, Nicolaie T, Tiuca N, Pop CS (25 September 2018). "Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study". Translational Gastroenterology and Hepatology. 3 (72). AME Publications: 72. doi:10.21037/tgh.2018.09.11. PMC 6256934. PMID 30511026.
  8. Biagioli E, Tarasco V, Lingua C, Moja L, Savino F (September 2016). "Pain-relieving agents for infantile colic". The Cochrane Database of Systematic Reviews. 2016 (9): CD009999. doi:10.1002/14651858.CD009999.pub2. PMC 6457752. PMID 27631535.
  9. Goldman M, Beaumont T (March 2017). "A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents". British Journal of Nursing. 26 (5 Suppl 1): S3 – S10. doi:10.12968/bjon.2017.26.Sup5.S3. PMID 28350192. S2CID 32885530.
  10. Voepel-Lewis TD, Malviya S, Burke C, D'Agostino R, Hadden SM, Siewert M, Tait AR (March 1998). "Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants". Journal of Clinical Anesthesia. 10 (2): 91–94. doi:10.1016/S0952-8180(97)00249-3. PMID 9524891.
  11. ^ Ingold CJ, Akhondi H (January 2021). "Simethicone". StatPearls . PMID 32310457.
  12. "Simethicone Side Effects in Detail". Drugs.com. Retrieved 27 August 2017.
  13. "Treatment of Gas". International Foundation for Functional Gastrointestinal Disorders. 4 September 2015.
  14. Brecević L, Bosan-Kilibarda I, Strajnar F (May 1994). "Mechanism of antifoaming action of simethicone". Journal of Applied Toxicology. 14 (3). Wiley: 207–11. doi:10.1002/jat.2550140311. PMID 8083482. S2CID 7453218. Retrieved 30 January 2020.
  15. Dittrich M, Miederer SE, Havertz B, Krastev R (12 May 2010). "Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro" [Defoaming and antifoaming action of simethicone in vitro] (PDF). Journal für Gastroenterologische und Hepatologische Erkrankungen. (in German). 8 (3). Krause & Pachernegg: 19–25.
  16. O'Neil MJ, ed. (2006). "Dimethicone". The Merck Index (14th ed.). Whitehouse Station, NJ: Merck. p. 545.
  17. "Recommended INN List 42" (PDF). WHO Drug Information. 13 (3): 202. 1999.
  18. ^ "Simeticone international brands". Drugs.com. Retrieved 27 August 2017.
Drugs for functional gastrointestinal disorders (A03)
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium

compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives
Categories: