Misplaced Pages

Isoaminile: Difference between revisions

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively← Previous editContent deleted Content addedVisualWikitext
Revision as of 23:01, 12 August 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChEMBL_Ref', 'ChEBI_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacology|erro← Previous edit Latest revision as of 14:02, 12 October 2024 edit undoJonRichfield (talk | contribs)Extended confirmed users8,036 edits Replaced citation demands with refsTag: 2017 wikitext editor 
(36 intermediate revisions by 25 users not shown)
Line 1: Line 1:
{{Short description|Chemical compound}}
{{Unreferenced|date=August 2009}}
{{Refimprove|date=November 2011}}


{{drugbox {{Drugbox
| Verifiedfields = changed
⚫ | UNII_Ref = {{fdacite|correct|FDA}}
⚫ | verifiedrevid = 447812653
⚫ | UNII = R4823W2PQL
⚫ | IUPAC_name = 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile
⚫ | verifiedrevid = 443328315
⚫ | image = isoaminile.png
⚫ | IUPAC_name = 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile

⚫ | image = isoaminile.png
<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|isoaminile}}
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | pregnancy_category =
⚫ | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫ | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫ | legal_status =
⚫ | routes_of_administration =

<!--Pharmacokinetic data-->
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
⚫ | CAS_number = 77-51-0
⚫ | ATC_prefix = R05
⚫ | ATC_suffix = DB04
⚫ | PubChem = 6481
⚫ | DrugBank_Ref = {{drugbankcite|changed|drugbank}}
⚫ | DrugBank = DB08944
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 6236 | ChemSpiderID = 6236
⚫ | UNII_Ref = {{fdacite|correct|FDA}}
| InChI = 1/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3
⚫ | UNII = R4823W2PQL
| InChIKey = WFLSCFISQHLEED-UHFFFAOYAP
⚫ | KEGG_Ref = {{keggcite|correct|kegg}}
⚫ | KEGG = D08088

<!--Chemical data-->
⚫ | C=16 | H=24 | N=2
| smiles = N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C | smiles = N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
Line 16: Line 50:
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = WFLSCFISQHLEED-UHFFFAOYSA-N | StdInChIKey = WFLSCFISQHLEED-UHFFFAOYSA-N
⚫ | CAS_number = 77-51-0
⚫ | ATC_prefix = R05
⚫ | ATC_suffix = DB04
⚫ | PubChem = 6481
⚫ | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫ | DrugBank =
⚫ | KEGG_Ref = {{keggcite|correct|kegg}}
⚫ | KEGG = D08088
⚫ | C=16 | H=24 | N=2
| molecular_weight = 244.375 g/mol
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | pregnancy_category=
⚫ | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫ | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫ | legal_status =
⚫ | routes_of_administration =
}} }}


'''Isoaminile''' is an ] (cough suppressant) used under the trade-name '''Peracon'''.<ref name=R1>{{cite book | vauthors = Chappel CI, von Seeman C | veditors = Ellis GP, West GB | chapter = Antitussive Drugs | title = Progress in Medicinal Chemistry | year = 1963 | volume = 3 | publisher = Butterworth | isbn = 978-0-444-53322-7 | pages = 114–115 | doi = 10.1016/S0079-6468(08)70117-6 | pmid = 14146305 | chapter-url = https://books.google.com/books?id=PcyoOmjvGzkC&pg=PA114 | access-date = 2013-09-12 }}</ref>
⚫ '''Isoaminile''' ('''Peracon''') is an ] structurally related to ]. ] effects have been noted from doses approximately 300 mg and above. The normal therapeutic dose is 40-80 mg of the cyclamate salt not to exceed five doses in a 24-hour period. In addition to central antitussive effects it is also an ], exhibiting both ] and ] actions.


⚫ The normal therapeutic dose is 40–80&nbsp;mg of the cyclamate salt, with a maximum of five doses in a 24-hour period.<ref name=R1/> In addition to its central antitussive effects, it is also an ], exhibiting both ] and ] actions.<ref name=R1/>


== References == == References ==
{{Reflist|2}} {{Reflist|2}}



{{Cough and cold preparations}} {{Cough and cold preparations}}

{{Hallucinogens}}
] ]
⚫ ]
] ]
⚫ ]
]




{{respiratory-system-drug-stub}} {{respiratory-system-drug-stub}}
{{hallucinogen-stub}}

Latest revision as of 14:02, 12 October 2024

Chemical compound
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "Isoaminile" – news · newspapers · books · scholar · JSTOR (November 2011) (Learn how and when to remove this message)
Pharmaceutical compound
Isoaminile
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.000.940 Edit this at Wikidata
Chemical and physical data
FormulaC16H24N2
Molar mass244.382 g·mol
3D model (JSmol)
SMILES
  • N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C
InChI
  • InChI=1S/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3
  • Key:WFLSCFISQHLEED-UHFFFAOYSA-N
  (what is this?)  (verify)

Isoaminile is an antitussive (cough suppressant) used under the trade-name Peracon.

The normal therapeutic dose is 40–80 mg of the cyclamate salt, with a maximum of five doses in a 24-hour period. In addition to its central antitussive effects, it is also an anticholinergic, exhibiting both antimuscarinic and antinicotinic actions.

References

  1. ^ Chappel CI, von Seeman C (1963). "Antitussive Drugs". In Ellis GP, West GB (eds.). Progress in Medicinal Chemistry. Vol. 3. Butterworth. pp. 114–115. doi:10.1016/S0079-6468(08)70117-6. ISBN 978-0-444-53322-7. PMID 14146305. Retrieved 2013-09-12.
Cough and cold preparations (R05)
Expectorants
Mucolytics
Cough suppressants
Opium alkaloids,
opioids,
and derivatives
Other


Stub icon

This drug article relating to the respiratory system is a stub. You can help Misplaced Pages by expanding it.

Categories: