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Revision as of 07:14, 1 September 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChEMBL_Ref', 'ChEBI_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report errors or bugs)← Previous edit Latest revision as of 14:02, 12 October 2024 edit undoJonRichfield (talk | contribs)Extended confirmed users8,036 edits Replaced citation demands with refsTag: 2017 wikitext editor 
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{{Short description|Chemical compound}}
{{Unreferenced|date=August 2009}}
{{Refimprove|date=November 2011}}


{{Drugbox {{Drugbox
| Verifiedfields = changed
| verifiedrevid = 444523558 | verifiedrevid = 447812653
| IUPAC_name = 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile | IUPAC_name = 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile
| image = isoaminile.png | image = isoaminile.png
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = | legal_status =
| routes_of_administration = | routes_of_administration =


<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
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| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =


<!--Identifiers--> <!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 77-51-0 | CAS_number = 77-51-0
| ATC_prefix = R05 | ATC_prefix = R05
| ATC_suffix = DB04 | ATC_suffix = DB04
| PubChem = 6481 | PubChem = 6481
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = | DrugBank = DB08944
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 6236 | ChemSpiderID = 6236
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<!--Chemical data--> <!--Chemical data-->
| C=16 | H=24 | N=2 | C=16 | H=24 | N=2
| molecular_weight = 244.375 g/mol
| smiles = N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C | smiles = N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C
| InChI = 1/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3
| InChIKey = WFLSCFISQHLEED-UHFFFAOYAP
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3 | StdInChI = 1S/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3
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}} }}


'''Isoaminile''' is an ] (cough suppressant) used under the trade-name '''Peracon'''.<ref name=R1>{{cite book | vauthors = Chappel CI, von Seeman C | veditors = Ellis GP, West GB | chapter = Antitussive Drugs | title = Progress in Medicinal Chemistry | year = 1963 | volume = 3 | publisher = Butterworth | isbn = 978-0-444-53322-7 | pages = 114–115 | doi = 10.1016/S0079-6468(08)70117-6 | pmid = 14146305 | chapter-url = https://books.google.com/books?id=PcyoOmjvGzkC&pg=PA114 | access-date = 2013-09-12 }}</ref>
⚫ '''Isoaminile''' ('''Peracon''') is an ] structurally related to ]. ] effects have been noted from doses approximately 300 mg and above. The normal therapeutic dose is 40-80 mg of the cyclamate salt not to exceed five doses in a 24-hour period. In addition to central antitussive effects it is also an ], exhibiting both ] and ] actions.


⚫ The normal therapeutic dose is 40–80&nbsp;mg of the cyclamate salt, with a maximum of five doses in a 24-hour period.<ref name=R1/> In addition to its central antitussive effects, it is also an ], exhibiting both ] and ] actions.<ref name=R1/>


== References == == References ==
{{Reflist|2}} {{Reflist|2}}



{{Cough and cold preparations}} {{Cough and cold preparations}}

{{Hallucinogens}}
] ]
⚫ ]
] ]
⚫ ]
]




{{respiratory-system-drug-stub}} {{respiratory-system-drug-stub}}
{{hallucinogen-stub}}

Latest revision as of 14:02, 12 October 2024

Chemical compound
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Find sources: "Isoaminile" – news · newspapers · books · scholar · JSTOR (November 2011) (Learn how and when to remove this message)
Pharmaceutical compound
Isoaminile
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • 4-(dimethylamino)-2-isopropyl-2-phenylpentanenitrile
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.000.940 Edit this at Wikidata
Chemical and physical data
FormulaC16H24N2
Molar mass244.382 g·mol
3D model (JSmol)
SMILES
  • N#CC(c1ccccc1)(C(C)C)CC(N(C)C)C
InChI
  • InChI=1S/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3
  • Key:WFLSCFISQHLEED-UHFFFAOYSA-N
  (what is this?)  (verify)

Isoaminile is an antitussive (cough suppressant) used under the trade-name Peracon.

The normal therapeutic dose is 40–80 mg of the cyclamate salt, with a maximum of five doses in a 24-hour period. In addition to its central antitussive effects, it is also an anticholinergic, exhibiting both antimuscarinic and antinicotinic actions.

References

  1. ^ Chappel CI, von Seeman C (1963). "Antitussive Drugs". In Ellis GP, West GB (eds.). Progress in Medicinal Chemistry. Vol. 3. Butterworth. pp. 114–115. doi:10.1016/S0079-6468(08)70117-6. ISBN 978-0-444-53322-7. PMID 14146305. Retrieved 2013-09-12.
Cough and cold preparations (R05)
Expectorants
Mucolytics
Cough suppressants
Opium alkaloids,
opioids,
and derivatives
Other


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