| Revision as of 14:05, 19 February 2011 editRjwilmsi (talk | contribs)Extended confirmed users, Pending changes reviewers, Rollbackers932,080 editsm Journal cites:, added 1 PMIDs, completed 1 page ranges, using AWB (7584)← Previous edit | Revision as of 14:15, 19 February 2011 edit undoCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'UNII_Ref', 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation (Next edit → | ||
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| | verifiedrevid = 407843385 | |||
| | IUPAC_name = Ethyl ''N''-vinyl]-3-methyl-1-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-3''H''-benzoisobenzofuran-7-yl]carbamate | | IUPAC_name = Ethyl ''N''-vinyl]-3-methyl-1-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-3''H''-benzoisobenzofuran-7-yl]carbamate | ||
| | synonyms = SCH-530348 | | synonyms = SCH-530348 | ||
Revision as of 14:15, 19 February 2011
Pharmaceutical compound | |
| Clinical data | |
|---|---|
| Other names | SCH-530348 |
| Identifiers | |
IUPAC name
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| CAS Number | |
| PubChem CID | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.116.767  |
| Chemical and physical data | |
| Formula | C29H33FN2O4 |
| Molar mass | 492.58 g/mol g·mol |
| (verify) | |
Vorapaxar (formerly SCH-530,348) is a thrombin receptor (PAR-1) antagonist based on the natural product himbacine. Discovered by Schering-Plough and currently being developed by Merck & Co., it is a experimental pharmaceutical treatment for acute coronary syndrome chest pain caused by coronary artery disease.
In January 2011, clinical trials being conducted by Merck were halted for patients with stroke and mild heart conditions. Merck is uncertain whether further development of vorapaxar will continue.
References
- Samuel Chackalamannil (2008). "Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity". Journal of Medicinal Chemistry. 51 (11): 3061–4. doi:10.1021/jm800180e. PMID 18447380.
- Merck Blood Thinner Studies Halted in Select Patients, Bloomberg News, January 13, 2011
External links
| Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01) | |||||||||||||||
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| Antiplatelet drugs |
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| Anticoagulants |
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| Thrombolytic drugs/ fibrinolytics | |||||||||||||||
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