Evoxine: Difference between revisions

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	{{~~drugbox~~		{{Drugbox
	\| verifiedrevid = 414055854		\| verifiedrevid = 414055854
	\| IUPAC_name = 1-(4,8-dimethoxyfuroquinolin-7-yl)oxy-3-methylbutane-2,3-diol		\| IUPAC_name = 1-(4,8-dimethoxyfuroquinolin-7-yl)oxy-3-methylbutane-2,3-diol
	\| image = Evoxine.png		\| image = Evoxine.png
	\| width = 200		\| width = 200

⚫	\| CAS_number = 522-11-2
			<!--Clinical data-->
⚫	\| ATC_prefix = none
	\| ~~ATC_suffix~~ =		\| tradename =
	\| ~~PubChem~~ = ~~73416~~		\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
	\| ~~DrugBank~~ =		\| pregnancy_US = <!-- A / B / C / D / X -->
			\| pregnancy_category =
⚫	\| C=11\|H=12\|O=2
		⚫	\| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫	\| molecular_weight = 347.362 g/mol
		⚫	\| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫	\| smiles = CC(C)(C(COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC)O)O
		⚫	\| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫	\| bioavailability =
		⚫	\| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
	\| protein_bound =
		⚫	\| legal_status = Legal
⚫	\| metabolism =
		⚫	\| routes_of_administration =
⚫	\| elimination_half-life =

⚫	\| excretion =
			<!--Pharmacokinetic data-->
	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
		⚫	\| bioavailability =
	\| pregnancy_US = <!-- A / B / C / D / X -->
	\| ~~pregnancy_category~~=		\| protein_bound =
		⚫	\| metabolism =
⚫	\| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
		⚫	\| elimination_half-life =
⚫	\| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
		⚫	\| excretion =
⚫	\| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->

⚫	\| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
			<!--Identifiers-->
⚫	\| legal_status = Legal
		⚫	\| CAS_number = 522-11-2
⚫	\| routes_of_administration =
		⚫	\| ATC_prefix = none
			\| ATC_suffix =
			\| PubChem = 73416
			\| DrugBank =

			<!--Chemical data-->
		⚫	\| C=11 \| H=12 \| O=2
		⚫	\| molecular_weight = 347.362 g/mol
		⚫	\| smiles = CC(C)(C(COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC)O)O
	}}		}}

Revision as of 11:10, 3 September 2011

Pharmaceutical compound

Evoxine
Clinical data

ATC code	none
Legal status
Legal status	In general: legal
Identifiers
IUPAC name 1-(4,8-dimethoxyfuroquinolin-7-yl)oxy-3-methylbutane-2,3-diol
CAS Number	522-11-2
PubChem CID	73416
CompTox Dashboard (EPA)	DTXSID801028138
Chemical and physical data
Formula	C₁₁H₁₂O₂
Molar mass	347.362 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES CC(C)(C(COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC)O)O
(verify)

Evoxine (Haploperine) is an alkaloid with hypnotic and sedative effects. It is found naturally in a variety of Australian and African plants including Evodia xanthoxyloides and Teclea gerrardii.

References

Eastwood, FW; Hughes, GK; Ritchie, E. (1954). "Alkaloids of the Australian Rutaceae: Evodia xanthoxyloides F.Muell. IV. The structures of Evoxine and Evoxoidine". Australian Journal of Chemistry. 7 (1): 87–98. doi:10.1071/CH9540087.
Waffo, AF; Coombes, PH; Crouch, NR; Mulholland, DA; El Amin, SM; Smith, PJ (2007). "Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa". Phytochemistry. 68 (5): 663–7. doi:10.1016/j.phytochem.2006.10.011. PMID 17174364.

Hypnotics/sedatives (N05C)

GABA_A

Alcohols	2M2B Chloralodol Ethanol (alcohol) Diethylpropanediol Ethchlorvynol Methylpentynol Trichloroethanol
Barbiturates	Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital Cyclobarbital Ethallobarbital Heptabarb Hexobarbital Mephobarbital Methohexital Narcobarbital Pentobarbital Phenallymal Phenobarbital Propylbarbital Proxibarbal Reposal Secobarbital Talbutal Thiamylal Thiopental Thiotetrabarbital Vinbarbital Vinylbital
Benzodiazepines	Brotizolam Cinolazepam Climazolam Clonazolam Doxefazepam Estazolam Flubromazolam Flunitrazolam Flunitrazepam Flurazepam Flutemazepam Flutoprazepam Loprazolam Lormetazepam Midazolam Nimetazepam Nitemazepam Nitrazepam Nitrazolam Quazepam Temazepam Triazolam
Carbamates	Carisoprodol Emylcamate Ethinamate Hexapropymate Meprobamate Methocarbamol Phenprobamate Procymate Tybamate
Imidazoles	Etomidate Metomidate Propoxate
Monoureides	Acecarbromal Apronal (apronalide) Bromisoval Capuride Carbromal Ectylurea
Neuroactive steroids	Acebrochol Allopregnanolone Alphadolone Alphaxolone Eltanolone Hydroxydione Minaxolone Progesterone
Nonbenzodiazepines	Eszopiclone Indiplon Lirequinil Necopidem Pazinaclone Saripidem Suproclone Suriclone Zaleplon Zolpidem Zopiclone
Phenols	Propofol
Piperidinediones	Glutethimide Methyprylon Pyrithyldione Piperidione
Quinazolinones	Afloqualone Cloroqualone Diproqualone Etaqualone Mebroqualone Mecloqualone Methaqualone Methylmethaqualone Nitromethaqualone SL-164
Others	Acetophenone Acetylglycinamide chloral hydrate Bromide compounds Lithium bromide Potassium bromide Sodium bromide Centalun Chloral betaine Chloral hydrate Chloralose Clomethiazole Dichloralphenazone Gaboxadol Kavalactones Loreclezole Paraldehyde Petrichloral Sulfonylalkanes Sulfonmethane (sulfonal) Tetronal Trional Triclofos Sesquiterpene Isovaleramide Isovaleric acid Valerenic acid

GABA_B

H₁

Antihistamines	Captodiame Cyproheptadine Diphenhydramine Doxylamine Hydroxyzine Methapyrilene Perlapine Pheniramine Promethazine Propiomazine
Antidepressants	Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine, etc. Tetracyclic antidepressants Mianserin Mirtazapine, etc.
Antipsychotics	Typical antipsychotics Chlorpromazine Thioridazine, etc. Atypical antipsychotics Olanzapine Quetiapine Risperidone, etc.

α₂-Adrenergic

5-HT_2A

Antidepressants	Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramine, etc. Tetracyclic antidepressants Mianserin Mirtazapine, etc.
Antipsychotics	Typical antipsychotics Chlorpromazine Thioridazine, etc. Atypical antipsychotics Olanzapine Quetiapine Risperidone, etc.
Others	Niaprazine

Melatonin

Orexin

α₂δ VDCC

Others

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