Misplaced Pages

Saripidem

Clinical data
ATC code	none
Identifiers
IUPAC name N-pyridin-3-yl]methyl]-N-methylbutanamide
CAS Number	103844-86-6
PubChem CID	3058746
ChemSpider	2319846
UNII	0J6174G60N
ChEMBL	ChEMBL73416
CompTox Dashboard (EPA)	DTXSID60146110
Chemical and physical data
Formula	C19H20ClN3O
Molar mass	341.84 g·mol
3D model (JSmol)	Interactive image
SMILES O=C(N(C)Cc1c(nc2ccccn12)c3ccc(Cl)cc3)CCC
InChI InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3 Key:LIFDPEORUVTOCP-UHFFFAOYSA-N
(what is this?)  (verify)

Saripidem is a sedative and anxiolytic drug in the imidazopyridine family, which is related to the better known drugs zolpidem and alpidem.

Saripidem has a similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but its chemical structure is quite different from that of the benzodiazepine drugs, and saripidem is described as a nonbenzodiazepine.

The mechanism of action by which saripidem produces its sedative and anxiolytic effects is by modulating the benzodiazepine binding site on GABA_A receptors, however unlike many older GABA_A agonists, saripidem is highly subtype selective and binds primarily to the ω1 subtype.

References

1. Sanger DJ (March 1995). "Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue". Behavioural Pharmacology. 6 (2): 116–126. doi:10.1097/00008877-199503000-00003. PMID 11224318. S2CID 42888705.

• Drugs not assigned an ATC code
• Carboxamides
• 4-Chlorophenyl compounds
• GABAA receptor positive allosteric modulators
• Imidazopyridines
• Sedatives