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Mizoribine: Difference between revisions

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Revision as of 02:11, 15 August 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation← Previous edit Revision as of 02:12, 3 September 2011 edit undoBogBot (talk | contribs)Bots53,132 edits populated new fields in {{drugbox}} and reordered per bot approval. Report errors and suggestions to User_talk:BogBotNext edit →
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{{drugbox {{Drugbox
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 4JR41A10VP
| verifiedrevid = 443489181 | verifiedrevid = 443489181
| IUPAC_name = 5-hydroxy-1-β-<small>D</small>-ribofuranosyl-1''H''-imidazole-4-carboxamide | IUPAC_name = 5-hydroxy-1-β-<small>D</small>-ribofuranosyl-1''H''-imidazole-4-carboxamide
| image = Mizoribine.png
|synonyms = <small>1--5-hydroxyimidazole-4-carboxamide</small>

| image = Mizoribine.png
<!--Clinical data-->
| CAS_number = 50924-49-7
| tradename =
| CAS_supplemental =
| Drugs.com = {{drugs.com|international|mizoribine}}
| ATC_prefix = none
| ATC_suffix = | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| ATC_supplemental =
| pregnancy_category =
| PubChem = 104762
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = Rx-only
| routes_of_administration = Oral

<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =

<!--Identifiers-->
| CAS_number = 50924-49-7
| ATC_prefix = none
| ATC_suffix =
| ATC_supplemental =
| PubChem = 104762
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = | DrugBank =
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 4JR41A10VP
| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01392 | KEGG = D01392

| chemical_formula =
<!--Chemical data-->
| chemical_formula =
| C=9 | H=13 | N=3 | O=6 | C=9 | H=13 | N=3 | O=6
| molecular_weight = 259.21 g/mol | molecular_weight = 259.21 g/mol
| smiles = C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N | smiles = C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
| synonyms = <small>1--5-hydroxyimidazole-4-carboxamide</small>
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category=
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = Rx-only
| routes_of_administration = Oral
}} }}



Revision as of 02:12, 3 September 2011

Pharmaceutical compound
Mizoribine
Clinical data
Other names1--5-hydroxyimidazole-4-carboxamide
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
IUPAC name
  • 5-hydroxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
CAS Number
PubChem CID
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.164.876 Edit this at Wikidata
Chemical and physical data
FormulaC9H13N3O6
Molar mass259.21 g/mol g·mol
3D model (JSmol)
SMILES
  • C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
  (verify)

Mizoribine (INN, trade name Bredinin) is an immunosuppresive drug. The compound was first observed in Tokyo, Japan, in 1971. It is a natural product, first isolated from the mould Eupenicillium brefeldianum.

References

  1. Hiroaki Ishikawa (1999). "Mizoribine and Mycophenolate Mofetil". Current Medicinal Chemistry. Bentham Science: 575–597. PMID 10390602.
Immunosuppressive drugs / Immunosuppressants (L04)
Intracellular
(initiation)
Antimetabolites
Macrolides/
other IL-2 inhibitors
IMiDs
Intracellular
(reception)
IL-1 receptor antagonists
mTOR
Extracellular
Antibodies
Monoclonal
Serum target
(noncellular)
Cellular
target
Unsorted
Polyclonal
-cept (Fusion)
Unsorted


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