Misplaced Pages

Inolimomab

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

Monoclonal antibody Pharmaceutical compound

Inolimomab
Monoclonal antibody
Type	Whole antibody
Source	Mouse
Target	CD25
Clinical data
ATC code	none
Identifiers
CAS Number	152981-31-2
ChemSpider	none
UNII	GO90DFK14U
(what is this?) (verify)

Inolimomab is a mouse monoclonal antibody developed as an immunosuppressive drug against graft-versus-host disease. Its target is the alpha chain of the interleukin-2 receptor.

References

Piñana JL, Valcárcel D, Martino R, Moreno ME, Sureda A, Briones J, et al. (November 2006). "Encouraging results with inolimomab (anti-IL-2 receptor) as treatment for refractory acute graft-versus-host disease". Biology of Blood and Marrow Transplantation. 12 (11): 1135–1141. doi:10.1016/j.bbmt.2006.06.010. PMID 17085306.
Dartois C, Freyer G, Michallet M, Hénin E, You B, Darlavoix I, et al. (2007). "Exposure-effect population model of inolimomab, a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease". Clinical Pharmacokinetics. 46 (5): 417–432. doi:10.2165/00003088-200746050-00004. PMC 2760126. PMID 17465640.

v
t
e

Immunosuppressive drugs / Immunosuppressants (L04)

Intracellular
(initiation)

Antimetabolites

purine synthesis inhibitors
- Azathioprine
- Mycophenolic acid

dihydroorotate dehydrogenase inhibitors
- Leflunomide
- Teriflunomide

antifolate
- Methotrexate

Macrolides/
other IL-2 inhibitors

FKBP/Cyclophilin/Calcineurin

Intracellular
(reception)

IL-1 receptor antagonists	Anakinra
mTOR	Everolimus Ridaforolimus Sirolimus Temsirolimus Umirolimus Zotarolimus

Extracellular

Serum target
(noncellular)

Complement component 5
- Eculizumab

TNF

Interleukin
- Anakinra
- Basiliximab
- Bimekizumab
- Briakinumab
- Brodalumab
- Canakinumab
- Daclizumab
- Guselkumab
- Ixekizumab
- Netakimab
- Olokizumab
- Rilonacept
- Risankizumab
- Sarilumab
- Satralizumab
- Secukinumab
- Siltuximab
- Sirukumab
- Spesolimab
- Tildrakizumab
- Tocilizumab
- Ustekinumab

Interleukin 5
- Mepolizumab

Immunoglobulin E
- Omalizumab

Interferon
- Faralimomab

IL-6
- Elsilimomab

IL-12, IL-13, and IL-23
- Lebrikizumab
- Ustekinumab

IL-17A
- Secukinumab

Cellular
target

IL-2 receptor/CD25

T-lymphocyte (Zolimomab aritox)

Unsorted

-cept (Fusion)

CTLA-4
- Abatacept
- Belatacept
TNF inhibitor
- Etanercept
- Opinercept
Aflibercept
Alefacept
Rilonacept

Unsorted

v
t
e

Monoclonal antibodies for the immune system

Human	Immunosuppression: Abrilumab Adalimumab Anifrolumab Atorolimumab Avelumab Avdoralimab Belimumab Bleselumab Brodalumab Camidanlumab tesirine Carlumab Cemiplimab Dupilumab Eldelumab Emapalumab Fresolimumab Golimumab Ianalumab Lanadelumab Lenzilumab Lerdelimumab Lirentelimab Lirilumab Mavrilimumab Metelimumab Morolimumab Namilumab Oleclumab Oxelumab§ Pamrevlumab Placulumab Relatlimab Sarilumab Sifalimumab Tabalumab Tezepelumab Ulocuplumab Varlilumab Immune activation: Ipilimumab Durvalumab Nivolumab Tremelimumab Urelumab Other: Bertilimumab Ontamalimab Zanolimumab Combination: Nivolumab/relatlimab
Mouse	Afelimomab Elsilimomab Faralimomab Gavilimomab Inolimomab Maslimomab Nerelimomab Odulimomab Telimomab aritox Vepalimomab Zolimomab aritox
Chimeric	Andecaliximab Basiliximab Clenoliximab Galiximab Gomiliximab Infliximab Keliximab Lumiliximab Priliximab Teneliximab Vapaliximab
Humanized	Immunosuppressive: Apolizumab Aselizumab Atezolizumab Benralizumab Camrelizumab Cedelizumab Certolizumab pegol Crizanlizumab Daclizumab Eculizumab Efalizumab Epratuzumab Erlizumab Etrolizumab Fontolizumab Frexalimab Inebilizumab Itolizumab Lampalizumab Letolizumab Ligelizumab Lulizumab pegol Mepolizumab Mogamulizumab Natalizumab Ocrelizumab (+hyaluronidase) Omalizumab Ozoralizumab Pascolizumab Pateclizumab Pembrolizumab Pexelizumab Pidilizumab Plozalizumab PRO 140 Quilizumab Ravulizumab Reslizumab Retifanlimab Rontalizumab Rovelizumab Ruplizumab Samalizumab Satralizumab Siplizumab Spartalizumab Talizumab Teclistamab Teplizumab Tislelizumab Tocilizumab Toralizumab Tregalizumab Vatelizumab Vedolizumab Visilizumab Vobarilizumab TGN1412 Immune activation: Dostarlimab Other: Ibalizumab
Chimeric + humanized	Otelixizumab Rozanolixizumab Sutimlimab

Human	Bermekimab Brazikumab Briakinumab Canakinumab Fezakinumab Fletikumab Guselkumab Secukinumab Sirukumab Tralokinumab Ustekinumab
Humanized	Anrukinzumab Bimekizumab Clazakizumab Gevokizumab Ixekizumab Mirikizumab Lebrikizumab Olokizumab Perakizumab Risankizumab Spesolimab Tildrakizumab
Veterinary	Lokivetmab

Inflammatory lesions

Mouse	Besilesomab Fanolesomab Lemalesomab Sulesomab

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

v
t
e

Interleukin receptor modulators

Decoy receptors: Rilonacept (IL-1 Trap)

Antagonists: Pitrakinra

Antibodies: Dupilumab
Pascolizumab

Agonists: Interleukin 5

Antagonists: YM-90709

Antisense oligonucleotides: TPI ASM8

Agonists: Atexakin alfa
Interleukin 6

Agonists: Interleukin 7

See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.

Agonists: Interleukin 9

Antibodies: Enokizumab

Agonists: Ilodecakin
Interleukin 10 (CSIF)

Agonists: Interleukin 11 (AGIF)
Oprelvekin

Agonists: Edodekin alfa
Interleukin 12

Antibodies: Briakinumab
Ustekinumab

Agonists: ALT-803
Interleukin 15

Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)

Binding proteins: IL18BP

Antibodies: Fletikumab (against IL-20)

Agonists: Denenicokin
Interleukin 21

Antibodies: NNC0114-0005
NNC0114-0006

Agonists: Interleukin 22

Antibodies: Fezakinumab (against IL-22)

Agonists: Interleukin 23 (SGRF)

Agonists: Interleukin 27 (interleukin 30)

Agonists: Interleukin 31

Agonists: Interleukin 33

Agonists: Interleukin 36 (α, β, γ)
Interleukin 38

Antagonists: IL-36RA

Others

See here instead.

Others

Interleukin 14 (taxilin alpha, HMW-BCGF)
Interleukin 16 (signals through CD4)
Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
Interleukin 32
Interleukin 34 (signals through M-CSFR/CSF1R)
Interleukin 35

Unsorted: Efavaleukin alfa
Efineptakin alfa

This monoclonal antibody–related article is a stub. You can help Misplaced Pages by expanding it.

v
t
e

This antineoplastic or immunomodulatory drug article is a stub. You can help Misplaced Pages by expanding it.

v
t
e