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The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130.

IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.

References

1. Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor". Biochem. Biophys. Res. Commun. 246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
2. Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR". Nature. 407 (6806): 916–20. Bibcode:2000Natur.407..916C. doi:10.1038/35038103. PMID 11057672. S2CID 205009928.
3. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". Journal of Immunology. 172 (4): 2225–31. doi:10.4049/jimmunol.172.4.2225. PMID 14764690.
4. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.

External links

• Receptors,+Interleukin-27 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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