| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | IL-4 |
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Pascolizumab is a humanized monoclonal antibody for the treatment of asthma. A Phase II clinical trial in patients with symptomatic glucocorticoid naive asthma was conducted in 2001/2002. Development was discontinued as it showed little benefit.
References
- Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM (October 2002). "Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma". Clinical and Experimental Immunology. 130 (1): 93–100. doi:10.1046/j.1365-2249.2002.01973.x. PMC 1906490. PMID 12296858.
- Clinical trial number NCT00024544 for "Pilot Study in Patients With Symptomatic Steroid-Naive Asthma" at ClinicalTrials.gov
- Bice JB, Leechawengwongs E, Montanaro A (2014). "Biologic targeted therapy in allergic asthma". Annals of Allergy, Asthma & Immunology. 112 (2): 108 - 115. doi:10.1016/j.anai.2013.12.013.
| Immunosuppressive drugs / Immunosuppressants (L04) | |||||||||||||||
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| Intracellular (initiation) |
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| Intracellular (reception) |
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| Extracellular |
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| Unsorted |
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| Interleukin receptor modulators | |||||
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| IL-1 |
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| IL-2 |
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| IL-3 | |||||
| IL-4 |
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| IL-5 |
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| IL-6 |
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| IL-7 |
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| IL-8 |
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| IL-9 |
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| IL-10 |
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| IL-11 |
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| IL-12 |
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| IL-13 |
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| IL-15 |
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| IL-17 |
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| IL-18 |
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| IL-20 |
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| IL-21 |
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| IL-22 |
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| IL-23 |
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| IL-27 |
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| IL-28 | |||||
| IL-31 |
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| IL1RL1 |
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| IL1RL2 |
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| Others |
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