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3-(Trifluoromethyl)aniline

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3-(Trifluoromethyl)aniline
Names
Preferred IUPAC name 3-(Trifluoromethyl)aniline
Other names 3-Aminobenzotrifluoride; m-ABTF; m-Trifluoromethylaniline, 3-(Trifluoromethyl)phenyl-1-amine
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.002.404 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C7H6F3N/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4H,11H2Key: VIUDTWATMPPKEL-UHFFFAOYSA-N
  • InChI=1/C7H6F3N/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4H,11H2Key: VIUDTWATMPPKEL-UHFFFAOYAM
SMILES
  • FC(F)(F)c1cc(N)ccc1
Properties
Chemical formula C7H6F3N
Molar mass 161.12 g/mol
Density 1.29 g/cm
Melting point 5 to 6 °C (41 to 43 °F; 278 to 279 K)
Boiling point 187 to 188 °C (369 to 370 °F; 460 to 461 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

3-(Trifluoromethyl)aniline is an organic compound with the formula CF3C6H4NH2. It is one of three isomers of trifluoromethylaniline. Classified as an aromatic amines, they are colorless liquids. The corresponding dimethylamino derivative is also known.

Drugs List

Used in the following list of Drugs:

  1. Atovaquone
  2. Colfenamate
  3. Etofenamate
  4. Floctafenine
  5. Flufenamic acid
  6. HT-2157
  7. Losulazine
  8. Morniflumate
  9. Niflumic acid
  10. Norflurazon
  11. Pentflutizide
  12. Prefenamate
  13. Salfluverine
  14. Talniflumate
  15. Triflocin
  16. Ticarbodine
  17. Ufenamate

Also used in the synthesis of 4-Chloro-7-(trifluoromethyl)quinoline intermediate:

  1. Antrafenine
  2. EHT-1864
  3. Florifenine
  4. Losulazine
  5. Trifluoroquine
  6. PC13544868 (antihypertensive)

References

  1. William A. Sheppard (1969). "m-Trifluoromethyl-N,N-Dimethylaniline". Organic Syntheses. 49: 111. doi:10.15227/orgsyn.049.0111.
  2. John M. McCall, U.S. patent 4,140,775 (1979 to Pharmacia and Upjohn Co).


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