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Vincamine

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Vincamine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • (3α,14β,16α)-14,15-dihydro-
    14-hydroxyeburnamenine-14-carboxylic acid methyl ester
    OR
    methyl (15R,17S,19R)-15-ethyl-17-hydroxy-1,11-diazapentacyclononadeca-2(7),3,5,8(18)-tetraene-17-carboxylate
CAS Number
PubChem CID
IUPHAR/BPS
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.015.070 Edit this at Wikidata
Chemical and physical data
FormulaC21H26N2O3
Molar mass354.44 g/mol g·mol
  (what is this?)  (verify)

Vincamine is a peripheral vasodilator that increases blood flow to the brain (sold under the trademark Oxybral) . It is an indole alkaloid (specifically a tryptamine) found in the leaves of Vinca minor, comprising about 25-65% of the indole alkaloids found in Vinca minor by weight. It is also found in the species Catharanthus roseus. It can be synthesized from related alkaloids.

Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes.

References

  1. Cook, P; James, I (Dec. 24, 1981). "Cerebral vasodilators". N Engl J Med. 305 (26): 1560–1564. doi:10.1056/NEJM198112243052604. PMID 7031468. {{cite journal}}: Check date values in: |date= (help)CS1 maint: multiple names: authors list (link)
  2. "Indole Alkaloids". Ullmann's Encyclopedia of Industrial Chemistry, Fifth Edition. Wiley-VCH. 1985. p. 393. ISBN 3-527-20100-9.

External links

See also

Peripheral vasodilators (C04)
Phenylethanolamine derivatives
Alpha blockers
Nicotinic acid and derivatives
Purine derivatives
Ergot alkaloids
Other peripheral vasodilators
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