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Bexlosteride

Clinical data
Other names	LY 300502
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name (4aR,10bR)-8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahydrobenzoquinolin-3(2H)-one
CAS Number	148905-78-6
PubChem CID	166562
ChemSpider	145762
UNII	36X732P4P0
ChEMBL	ChEMBL24955
Chemical and physical data
Formula	C14H16ClNO
Molar mass	249.74 g·mol
3D model (JSmol)	Interactive image
SMILES CN12CCc3cc(ccc32CCC1=O)Cl
InChI InChI=1S/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m1/s1 Key:WQBIOEFDDDEARX-CHWSQXEVSA-N
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Bexlosteride is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride. It is selective for the type I isoform of the enzyme. It advanced to Phase III clinical trials, but development was halted at that stage, and it was never marketed.

See also

• 5α-Reductase inhibitor

References

1. ^ Chang C (2002). Androgens and androgen receptor : mechanisms, functions, and clinical application. Boston: Kluwer Academic Publishers. ISBN 1-4020-7188-4.
2. Lednicer D (2008). Strategies for Organic Drug Synthesis and Design. New York: Wiley-Interscience. ISBN 978-0-470-19039-5.
3. "Drug Profile: Bexlosteride". Adis Insight.
4. Reaxys entry for bexlosteride: Reaxys Registry Number: 6635310

• Drugs not assigned an ATC code
• 5α-Reductase inhibitors
• Delta-lactams
• Chloroarenes
• Benzoquinolines
• Abandoned drugs