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DNAJC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQQ, 2CQR
Identifiers
Aliases	DNAJC1, DNAJL1, ERdj1, HTJ1, MTJ1, DnaJ heat shock protein family (Hsp40) member C1
External IDs	OMIM: 611207; MGI: 103268; HomoloGene: 7293; GeneCards: DNAJC1; OMA:DNAJC1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.31 Start 21,756,548 bp End 22,003,769 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 18,200,465 bp End 18,397,641 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pylorus cardia parotid gland lower lobe of lung lactiferous duct pericardium renal medulla mucosa of paranasal sinus tibia Top expressed in lacrimal gland parotid gland seminal vesicula external carotid artery internal carotid artery prostate lobe of prostate Rostral migratory stream body of femur decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding ATPase activator activity chaperone binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component integral component of membrane organelle membrane plasma membrane nuclear membrane endoplasmic reticulum membrane endoplasmic reticulum membrane nucleus intracellular membrane-bounded organelle Biological process negative regulation of proteolysis protein folding regulation of translation regulation of protein secretion positive regulation of ATP-dependent activity regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64215 13418 Ensembl ENSG00000136770 ENSMUSG00000026740 UniProt Q96KC8 Q61712 RefSeq (mRNA) NM_022365 NM_001190817 NM_007869 RefSeq (protein) NP_071760 NP_001177746 NP_031895 Location (UCSC) Chr 10: 21.76 – 22 Mb Chr 2: 18.2 – 18.4 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily C member 1 is a protein that in humans is encoded by the DNAJC1 gene.

Interactions

DNAJC1 has been shown to interact with Alpha 1-antichymotrypsin.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000136770 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026740 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1".
6. Kroczynska B, Evangelista CM, Samant SS, Elguindi EC, Blond SY (2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352.

Further reading

• Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4". Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chevalier M, Rhee H, Elguindi EC, Blond SY (2000). "Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1". J. Biol. Chem. 275 (26): 19620–7. doi:10.1074/jbc.M001333200. PMC 1534116. PMID 10777498.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human DnaJ homolog subfamily C member 1

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