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Eperezolid

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Chemical compound Pharmaceutical compound

Eperezolid
Clinical data


ATC code	none
Identifiers
IUPAC name (S)-N-phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
CAS Number	165800-04-4
PubChem CID	73214
ChemSpider	65969
UNII	C460ZSU1OW
KEGG	D04017
ChEMBL	ChEMBL47955
CompTox Dashboard (EPA)	DTXSID50168028
Chemical and physical data
Formula	C₁₈H₂₃FN₄O₅
Molar mass	394.403 g·mol
3D model (JSmol)	Interactive image
SMILES CC(=O)NC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCN(CC3)C(=O)CO)F
InChI InChI=1S/C18H23FN4O5/c1-12(25)20-9-14-10-23(18(27)28-14)13-2-3-16(15(19)8-13)21-4-6-22(7-5-21)17(26)11-24/h2-3,8,14,24H,4-7,9-11H2,1H3,(H,20,25)/t14-/m0/s1 Key:SIMWTRCFFSTNMG-AWEZNQCLSA-N
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Eperezolid is an oxazolidinone antibiotic.

Synthesis

Eperezolid synthesis

See also

Linezolid

References

Brickner SJ, Hutchinson DK, Barbachyn MR, Manninen PR, Ulanowicz DA, Garmon SA, et al. (February 1996). "Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections". Journal of Medicinal Chemistry. 39 (3): 673–9. doi:10.1021/jm9509556. PMID 8576909.

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Antibacterials that inhibit protein synthesis (J01A, J01B, J01F, J01G, QJ01XQ)

Aminoglycosides
(initiation inhibitors)

-mycin (Streptomyces)

Neomycin

Kanamycin

-micin (Micromonospora)

Gentamicin

other

Butirosin

Tetracycline antibiotics
(tRNA binding)

Tetracyclines	Doxycycline Chlortetracycline Clomocycline Demeclocycline Eravacycline Lymecycline Meclocycline Metacycline Minocycline Omadacycline Oxytetracycline Penimepicycline Rolitetracycline Sarecycline Tetracycline
Glycylcyclines	Tigecycline

Oxazolidinone
(initiation inhibitors)

Peptidyl transferase

Amphenicols	Chloramphenicol Azidamfenicol Thiamphenicol Florfenicol

MLS (transpeptidation/translocation)

Macrolides	Azithromycin Boromycin Carbomycin Carrimycin Clarithromycin Dirithromycin Erythromycin Flurithromycin Gamithromycin Josamycin Kitasamycin Midecamycin Miocamycin Nafithromycin Oleandomycin Rokitamycin Roxithromycin Solithromycin Spiramycin Telithromycin Tildipirosin Tilmicosin Troleandomycin Tulathromycin Tylosin Tylvalosin
Ketolides	Telithromycin Cethromycin Solithromycin
Lincosamides	Clindamycin Lincomycin Pirlimycin
Streptogramins	Pristinamycin (IA, IIA, IIB) NXL103 (Flopristin, Linopristin) Quinupristin/dalfopristin (Dalfopristin, Quinupristin) Streptogramin A Streptogramin B Virginiamycin (S1)

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

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