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Losoxantrone

Identifiers
IUPAC name 7-Hydroxy-2-{2-ethyl}-5-({2-ethyl}amino)dibenzoindazol-6(2H)-one
CAS Number	88303-60-0
PubChem CID	72116
ChemSpider	65094
UNII	47KPH00809
CompTox Dashboard (EPA)	DTXSID60236949
Chemical and physical data
Formula	C22H27N5O4
Molar mass	425.489 g·mol
3D model (JSmol)	Interactive image
SMILES c1cc-2c(c(c1)O)C(=O)c3c(ccc4c3c2nn4CCNCCO)NCCNCCO
InChI InChI=InChI=1S/C22H27N5O4/c28-12-9-23-6-7-25-15-4-5-16-20-19(15)22(31)18-14(2-1-3-17(18)30)21(20)26-27(16)11-8-24-10-13-29/h1-5,23-25,28-30H,6-13H2 Key:YROQEQPFUCPDCP-UHFFFAOYSA-N

Losoxantrone (biantrazole) is an anthroquinone anthrapyrazole antineoplastic agent and analog of mitoxantrone. It is also sometimes known as DuP 941.

See also

• Mitoxantrone
• Piroxantrone

References

1. Showalter HD, Johnson JL, Hoftiezer JM, Turner WR, Werbel LM, Leopold WR, et al. (January 1987). "Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias". Journal of Medicinal Chemistry. 30 (1): 121–31. doi:10.1021/jm00384a021. PMID 3806589.
2. Beylin VG, Colbry NL, Goel OP, Haky JE, Johnson DR, Johnson JL, Kanter GD, Leeds RL, Leja B, Lewis EP, Rithner CD (1989). "Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride". Journal of Heterocyclic Chemistry. 26: 85–96. doi:10.1002/jhet.5570260117.
3. Leteurtre F, Kohlhagen G, Paull KD, Pommier Y (August 1994). "Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen". Journal of the National Cancer Institute. 86 (16): 1239–44. doi:10.1093/jnci/86.16.1239. PMID 8040892.

• Antineoplastic drugs
• Topoisomerase inhibitors
• Amines
• Primary alcohols
• Nitrogen heterocycles
• Heterocyclic compounds with 4 rings
• Hydroxyarenes
• Ethanolamines
• Tetracyclic compounds
• Triolena