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Triethylenemelamine

Clinical data
ATC code	None
Identifiers
IUPAC name 2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine
CAS Number	51-18-3
PubChem CID	5799
ChemSpider	5594
UNII	F7IY6HZG9D
KEGG	C07642
ChEMBL	ChEMBL502384
CompTox Dashboard (EPA)	DTXSID3026225
ECHA InfoCard	100.000.076
Chemical and physical data
Formula	C9H12N6
Molar mass	204.237 g·mol
3D model (JSmol)	Interactive image
SMILES C1CN1c2nc(nc(n2)N3CC3)N4CC4
InChI InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2 Key:IUCJMVBFZDHPDX-UHFFFAOYSA-N
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Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.

It can cause chromatid aberrations in cell models.

See also

• Altretamine
• thiotepa

References

1. Wong JR, Morton LM, Tucker MA, Abramson DH, Seddon JM, Sampson JN, Kleinerman RA (October 2014). "Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy". Journal of Clinical Oncology. 32 (29): 3284–3290. doi:10.1200/JCO.2013.54.7844. PMC 4178525. PMID 25185089.
2. Luippold HE, Gooch PC, Brewen JG (February 1978). "The production of chromosome aberrations in various mammalian cells by triethylenemelamine". Genetics. 88 (2): 317–326. doi:10.1093/genetics/88.2.317. PMC 1213803. PMID 565312.

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• Drugs not assigned an ATC code
• Alkylating antineoplastic agents
• Triazines
• 1-Aziridinyl compounds
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