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Monocarboxylate transporter 3

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(Redirected from SLC16A8) Protein-coding gene in the species Homo sapiens
SLC16A8
Identifiers
AliasesSLC16A8, MCT3, REMP, solute carrier family 16 member 8
External IDsOMIM: 610409; MGI: 1929519; HomoloGene: 75006; GeneCards: SLC16A8; OMA:SLC16A8 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)
Chromosome 22 (human)Genomic location for SLC16A8Genomic location for SLC16A8
Band22q13.1Start38,078,134 bp
End38,084,184 bp
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)
Chromosome 15 (mouse)Genomic location for SLC16A8Genomic location for SLC16A8
Band15|15 E1Start79,135,214 bp
End79,138,961 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • testicle

  • nucleus accumbens

  • sural nerve

  • gonad

  • C1 segment

  • right uterine tube

  • putamen

  • Descending thoracic aorta

  • ascending aorta
Top expressed in
  • retinal pigment epithelium

  • choroid plexus of fourth ventricle

  • Epithelium of choroid plexus

  • gastrula

  • embryo

  • CA3 field

  • ciliary body

  • embryo

  • saccule

  • ectoderm
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23539

57274

Ensembl

ENSG00000100156

ENSMUSG00000032988

UniProt

O95907

O35308

RefSeq (mRNA)

NM_013356
NM_001394131

NM_020516

RefSeq (protein)

NP_037488

NP_065262

Location (UCSC)Chr 22: 38.08 – 38.08 MbChr 15: 79.14 – 79.14 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene. MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000100156 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032988 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.

Further reading

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
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SLC11–20
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SLC21–30
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SLC31–40
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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