TRV734 - Misplaced Pages

Chemical compound Pharmaceutical compound

TRV734
Identifiers

IUPAC name N--2-decan-9-yl]ethanamine
PubChem CID	72695064
Chemical and physical data
Formula	C₂₂H₂₈FN₃O
Molar mass	369.484 g·mol
3D model (JSmol)	Interactive image
SMILES C1CCC2(C1)C(CCO2)(CCNCC3=CC(=CN=C3)F)C4=CC=CC=N4
InChI InChI=1S/C22H28FN3O/c23-19-13-18(15-25-16-19)14-24-11-8-21(20-5-1-4-10-26-20)9-12-27-22(17-21)6-2-3-7-22/h1,4-5,10,13,15-16,24H,2-3,6-9,11-12,14,17H2/t21-/m1/s1 Key:CRKVMJHROLSFMV-OAQYLSRUSA-N

TRV734 is a drug developed by Trevena Inc which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It is closely related to oliceridine and has a similar pharmacological profile, but unlike oliceridine which has to be injected, TRV734 is suitable to be administered orally.

References

James IE, Skobieranda F, Soergel DG, Ramos KA, Ruff D, Fossler MJ (February 2020). "A First-in-Human Clinical Study With TRV734, an Orally Bioavailable G-Protein-Biased Ligand at the μ-Opioid Receptor". Clinical Pharmacology in Drug Development. 9 (2): 256–266. doi:10.1002/cpdd.721. PMID 31286645. S2CID 195843184.