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'''Afelimomab''' ('''MAK 195F''') is an anti-] ]. Administration of afelimomab reduces the concentration of ]-6 in patients with ], but reduces ] only marginally.<ref>{{cite journal | vauthors = Rondon E, Venkataraman R | title = Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels | journal = Critical Care | volume = 9 | issue = 5 | pages = E20 | date = August 2005 | pmid = 16277704 | pmc = 1297624 | doi = 10.1186/cc3798 }}</ref><ref>{{cite journal | vauthors = Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, Miller M, Barchuk WT, Fischkoff S, Kaul M, Teoh L, Van Meter L, Daum L, Lemeshow S, Hicklin G, Doig C | display-authors = 6 | title = Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels | journal = Critical Care Medicine | volume = 32 | issue = 11 | pages = 2173–82 | date = November 2004 | pmid = 15640628 | doi = 10.1097/01.CCM.0000145229.59014.6C | author17 = Monoclonal Anti-TNF: a Randomized Controlled Sepsis Study Investigators }}</ref> '''Afelimomab''' ('''MAK 195F''') is an anti-] ]. Administration of afelimomab reduces the concentration of ]-6 in patients with ], but reduces ] only marginally.<ref>{{cite journal | vauthors = Rondon E, Venkataraman R | title = Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels | journal = Critical Care | volume = 9 | issue = 5 | pages = E20 | date = August 2005 | pmid = 16277704 | pmc = 1297624 | doi = 10.1186/cc3798 }}</ref><ref>{{cite journal | vauthors = Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, Miller M, Barchuk WT, Fischkoff S, Kaul M, Teoh L, Van Meter L, Daum L, Lemeshow S, Hicklin G, Doig C | display-authors = 6 | title = Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels | journal = Critical Care Medicine | volume = 32 | issue = 11 | pages = 2173–82 | date = November 2004 | pmid = 15640628 | doi = 10.1097/01.CCM.0000145229.59014.6C | author17 = Monoclonal Anti-TNF: a Randomized Controlled Sepsis Study Investigators | s2cid = 23321488 }}</ref>


== References == == References ==

Revision as of 03:49, 12 September 2020

Pharmaceutical compound
Afelimomab
Monoclonal antibody
TypeF(ab')2 fragment
SourceMouse
TargetTNFα
Clinical data
ATC code
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
  (what is this?)  (verify)

Afelimomab (MAK 195F) is an anti-TNFα monoclonal antibody. Administration of afelimomab reduces the concentration of interleukin-6 in patients with sepsis, but reduces mortality only marginally.

References

  1. Rondon E, Venkataraman R (August 2005). "Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels". Critical Care. 9 (5): E20. doi:10.1186/cc3798. PMC 1297624. PMID 16277704.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  2. Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, et al. (November 2004). "Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels". Critical Care Medicine. 32 (11): 2173–82. doi:10.1097/01.CCM.0000145229.59014.6C. PMID 15640628. S2CID 23321488.
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