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Perfosfamide

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Pharmaceutical compound
Perfosfamide
File:4hydroxycyclophosphamide.png
Identifiers
IUPAC name
  • 2--4-hydroxy-2H1,3,2-oxazaphosphinan-2-one
CompTox Dashboard (EPA)
Chemical and physical data
FormulaCl2H15N2O3P
Molar mass193.00 g·mol
3D model (JSmol)
SMILES
  • OC1CCOP(=O)(N1)N(CCCl)CCCl

4-Hydroxycyclophosphamide is the main, active metabolite of cyclophosphamide.

References

  1. Van Der Steen, J.; Timmer, E. C.; Westra, J. G.; Benckhuysen, C. (1973). "4-Hydroperoxidation in the Fenton oxidation of the antitumor agent cyclophosphamide". J. Am. Chem. Soc. 95: 7535. doi:10.1021/ja00803a070.
  2. Wright, JE; Tretyakov, O; Ayash, LJ; Elias, A; Rosowsky, A; Frei E, 3rd (1995). "Analysis of 4-hydroxycyclophosphamide in human blood". Analyt. Biochem. 224 (1): 154–158. doi:10.1006/abio.1995.1021. PMID 7710063.{{cite journal}}: CS1 maint: numeric names: authors list (link)
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