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COPB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifiers
Aliases	COPB1, COPB, coatomer protein complex subunit beta 1, COPI coat complex subunit beta 1, BARMACS
External IDs	OMIM: 600959; MGI: 1917599; HomoloGene: 5664; GeneCards: COPB1; OMA:COPB1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.2 Start 14,443,440 bp End 14,500,027 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F1|7 59.31 cM Start 113,814,794 bp End 113,853,946 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus pancreatic ductal cell corpus epididymis caput epididymis endothelial cell germinal epithelium epithelium of nasopharynx tibia tail of epididymis jejunal mucosa Top expressed in parotid gland basilar part of occipital bone secondary oocyte dermis molar calvaria islet of Langerhans endocardial cushion submandibular gland atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding Cellular component Golgi apparatus membrane intracellular membrane-bounded organelle Golgi membrane COPI-coated vesicle membrane transport vesicle Golgi-associated vesicle membrane coat cytoplasmic vesicle COPI-coated vesicle endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum membrane cytoplasm cytosol plasma membrane COPI vesicle coat secretory granule membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process protein transport intracellular protein transport viral process vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum intra-Golgi vesicle-mediated transport neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1315 70349 Ensembl ENSG00000129083 ENSMUSG00000030754 UniProt P53618 Q9JIF7 RefSeq (mRNA) NM_016451 NM_001144061 NM_001144062 NM_033370 RefSeq (protein) NP_001137533 NP_001137534 NP_057535 NP_203534 Location (UCSC) Chr 11: 14.44 – 14.5 Mb Chr 7: 113.81 – 113.85 Mb PubMed search
Wikidata
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Coatomer subunit beta is a protein that in humans is encoded by the COPB1 gene.

See also

• COPI coatomer, a protein complex

References

1. ^ GRCh38: Ensembl release 89: ENSG00000129083 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030754 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Benichou S, Bomsel M, Bodeus M, Durand H, Doute M, Letourneur F, Camonis J, Benarous R (Dec 1994). "Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic". J Biol Chem. 269 (48): 30073–6. doi:10.1016/S0021-9258(18)43773-8. PMID 7982906.

Further reading

• Benichou S, Liu LX, Erdtmann L, et al. (1997). "Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein". Res. Virol. 148 (1): 71–3. doi:10.1016/S0923-2516(97)81918-8. PMID 9017839.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure–function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
• Duden R, Griffiths G, Frank R, et al. (1991). "Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin". Cell. 64 (3): 649–65. doi:10.1016/0092-8674(91)90248-W. PMID 1840503. S2CID 54293222.
• Waters MG, Serafini T, Rothman JE (1991). "'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles". Nature. 349 (6306): 248–51. Bibcode:1991Natur.349..248W. doi:10.1038/349248a0. PMID 1898986. S2CID 4342145.
• Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature. 364 (6439): 732–4. Bibcode:1993Natur.364..732O. doi:10.1038/364732a0. PMID 8355790. S2CID 4348442.
• Aniento F, Gu F, Parton RG, Gruenberg J (1996). "An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes" (PDF). J. Cell Biol. 133 (1): 29–41. doi:10.1083/jcb.133.1.29. PMC 2120778. PMID 8601610.
• Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. 271 (48): 30725–30. doi:10.1074/jbc.271.48.30725. PMID 8940050.
• Hansen K, Rönnstrand L, Rorsman C, et al. (1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. Commun. 235 (3): 455–60. doi:10.1006/bbrc.1997.6821. PMID 9207175.
• Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: Functional characterization of a β/δ-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. Bibcode:1998PNAS...95.2140P. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
• Piguet V, Gu F, Foti M, et al. (1999). "Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes". Cell. 97 (1): 63–73. doi:10.1016/S0092-8674(00)80715-1. PMID 10199403. S2CID 14793848.
• Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23". J. Biol. Chem. 274 (20): 14198–203. doi:10.1074/jbc.274.20.14198. PMID 10318838.
• Fischer KD, Helms JB, Zhao L, Wieland FT (2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles". Methods. 20 (4): 455–64. doi:10.1006/meth.2000.0958. PMID 10720466.
• Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. Bibcode:2000Sci...289..444A. doi:10.1126/science.289.5478.444. PMID 10903204.
• Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
• Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 Bind Coatomer and Inhibit COPI Association with Golgi Membranes and Intracellular Transport". Mol. Biol. Cell. 11 (9): 3155–68. doi:10.1091/mbc.11.9.3155. PMC 14982. PMID 10982407.
• Futatsumori M, Kasai K, Takatsu H, et al. (2001). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

External links

• Human COPB1 genome location and COPB1 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Coatomer subunit beta

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