Etoxeridine - Misplaced Pages

(Redirected from Carbetidine) Chemical compound Pharmaceutical compound

Etoxeridine
Clinical data

Other names	Etoxeridine, Carbetidine, Atenos
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class A1 (Narcotic drugs) CA: Schedule I DE: Anlage I (Authorized scientific use only) UK: Class A US: Schedule I
Identifiers
IUPAC name Ethyl 1--4-phenylpiperidine-4-carboxylate
CAS Number	469-82-9
PubChem CID	61122
DrugBank	DB01505
ChemSpider	55070
UNII	RHW35E1G7E
KEGG	D12680
ChEMBL	ChEMBL2104254
CompTox Dashboard (EPA)	DTXSID30196980
ECHA InfoCard	100.006.750
Chemical and physical data
Formula	C₁₈H₂₇NO₄
Molar mass	321.417 g·mol
3D model (JSmol)	Interactive image
SMILES C1(CCN(CC1)CCOCCO)(C(=O)OCC)C2=CC=CC=C2
InChI InChI=1S/C18H27NO4/c1-2-23-17(21)18(16-6-4-3-5-7-16)8-10-19(11-9-18)12-14-22-15-13-20/h3-7,20H,2,8-15H2,1H3 Key:KJTKYGFGPQSRRA-UHFFFAOYSA-N
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Etoxeridine (Carbetidine, Atenos) is a 4-phenyl piperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine).

Etoxeridine was developed in the 1950s and investigated for use in surgical anesthesia, however it was never commercialized and is not currently used in medicine. As with other opioids which were not in clinical use during the drafting of the Controlled Substances Act, it is categorized as a Schedule I narcotic.

References

Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
BE 558883
Merlevede E, Levis S (1958). "Pharmacological study of carbetidine, a new synthetic analgesic". Archives Internationales de Pharmacodynamie et de Thérapie (in French). 115 (1–2): 213–232. PMID 13545901.
Sironi PG (1959). "Brief note on a new synthetic analgesic: carbetidine hydrochloride". Minerva Anestesiologica (in Italian). 25 (6): 251–254. PMID 13674097.
Crawford JS, Foldes FF (August 1959). "Studies on the respiratory and circulatory effects of carbetidine HCI used for supplementation of thiopentone sodium-nitrous oxide-oxygen anaesthesia". British Journal of Anaesthesia. 31 (8): 348–51. doi:10.1093/bja/31.8.348. PMID 13812715.