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In molecular biology, the EcoEI R protein C-terminal domain is a protein domain found at the C-terminus of both the R subunit of type I restriction enzymes and the Res subunit of type III restriction enzymes. The type I enzymes include EcoEI, which recognises 5'-GAGN(7)ATGC-3; the R protein (HsdR) is required for both nuclease and ATPase activity.

References

1. Murray NE, Daniel AS, Cowan GM, Sharp PM (July 1993). "Conservation of motifs within the unusually variable polypeptide sequences of type I restriction and modification enzymes". Mol. Microbiol. 9 (1): 133–43. doi:10.1111/j.1365-2958.1993.tb01675.x. PMID 8412658. S2CID 45127462.
2. Makovets S, Doronina VA, Murray NE (August 1999). "Regulation of endonuclease activity by proteolysis prevents breakage of unmodified bacterial chromosomes by type I restriction enzymes". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9757–62. Bibcode:1999PNAS...96.9757M. doi:10.1073/pnas.96.17.9757. PMC 22283. PMID 10449767.

• Protein families
• Protein domains