Misplaced Pages

CGI-121
crystal structure of pfu-542154 conserved hypothetical protein
Identifiers
Symbol	CGI-121
Pfam	PF08617
InterPro	IPR013926
SCOP2	1zd0 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the kinase binding protein CGI-121 family of proteins includes the kinase binding protein CGI-121 and its homologues. CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. This family of proteins also include archaeal homologues.

References

1. Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (April 2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein". Biochem. Biophys. Res. Commun. 303 (2): 399–405. doi:10.1016/S0006-291X(03)00333-4. PMID 12659830.
2. Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (March 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.

• Protein domains
• Telomeres
• Telomere-related proteins