Inhibitor of apoptosis domain

Protein domain

Inhibitor of Apoptosis domain

NMR solution structure of the BIR domain of human BIRC2 protein. The protein is rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) while the coordinated zinc is represented by a grey sphere.

Identifiers

Symbol

BIR

1qbh / SCOPe / SUPFAM

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1c9q, 1e31, 1f3h, 1f9x, 1g3f, 1g73, 1i3o, 1jd4, 1jd5, 1jd6, 1m4m, 1nw9, 1oxn, 1oxq, 1oy7, 1q4q, 1qbh, 1sdz, 1se0, 1tfq, 1tft, 1tw6, 1xb0, 1xb1, 1xox, 2i3h, 2i3i

The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6.

BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.

External links

Eukaryotic Linear Motif resource motif class LIG_BIR_II_1
Eukaryotic Linear Motif resource motif class LIG_BIR_III_1
Eukaryotic Linear Motif resource motif class LIG_BIR_III_2
Eukaryotic Linear Motif resource motif class LIG_BIR_III_3
Eukaryotic Linear Motif resource motif class LIG_BIR_III_4

v t e Protein domains
3H ABM ACDC ACT ADF-H ANTH ARID BAR BEN BESS BIR BMC BPS BTB/POZ BZIP C1 C2 Cache CBS CGI-121 CRM CUB CUT CVHN Death DD DED CARD Pyrin DEP DHHC DHR1 DHR2 DM EcoEI_R_C EF1 ENTH FGGY FYVE HEAT Kringle LIM LRR NACHT PAS LOV PDZ PH PX SH2 SH3 SUN TRIO WD40 X8 YTH zinc finger

References

PDB: 1QBH;Hinds MG, Norton RS, Vaux DL, Day CL (July 1999). "Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat". Nat. Struct. Biol. 6 (7): 648–51. doi:10.1038/10701. PMID 10404221. S2CID 3194182.
^ Silke J, Vaux DL (May 2001). "Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis". J. Cell Sci. 114 (Pt 10): 1821–7. doi:10.1242/jcs.114.10.1821. PMID 11329368.
Verhagen AM, Coulson EJ, Vaux DL (2001). "Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs". Genome Biol. 2 (7): REVIEWS3009. doi:10.1186/gb-2001-2-7-reviews3009. PMC 139420. PMID 11516343.
Birnbaum MJ, Clem RJ, Miller LK (April 1994). "An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs". J. Virol. 68 (4): 2521–8. doi:10.1128/JVI.68.4.2521-2528.1994. PMC 236730. PMID 8139034.

This article incorporates text from the public domain Pfam and InterPro: IPR001370 Categories: