Ibafloxacin - Misplaced Pages

Chemical compound Pharmaceutical compound

Ibafloxacin
Clinical data

Trade names	Ibaflin
AHFS/Drugs.com	International Drug Names
ATCvet code	QJ01MA96 (WHO)
Legal status
Legal status	CA: ℞-only EU: Rx-only
Identifiers
IUPAC name 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzoquinolizine-2-carboxylic acid
CAS Number	91618-36-9
PubChem CID	71186
ChemSpider	64324
UNII	53VPK9R0T5
KEGG	D04485
CompTox Dashboard (EPA)	DTXSID8057853
Chemical and physical data
Formula	C₁₅H₁₄FNO₃
Molar mass	275.279 g·mol
3D model (JSmol)	Interactive image
SMILES Fc2cc1C(=O)/C(C(=O)O)=C\N3c1c(c2C)CCC3C
InChI InChI=1S/C15H14FNO3/c1-7-3-4-9-8(2)12(16)5-10-13(9)17(7)6-11(14(10)18)15(19)20/h5-7H,3-4H2,1-2H3,(H,19,20) Key:DXKRGNXUIRKXNR-UHFFFAOYSA-N
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Ibafloxacin (INN) is a fluoroquinolone antibiotic drug formally approved for use in the European Union for veterinary medicine.

References

Horspool LJ, van Laar P, van den Bos R, Mawhinney I (June 2004). "Treatment of canine pyoderma with ibafloxacin and marbofloxacin--fluoroquinolones with different pharmacokinetic profiles". Journal of Veterinary Pharmacology and Therapeutics. 27 (3): 147–53. doi:10.1111/j.1365-2885.2004.00561.x. PMID 15189300.
"EUROPEAN PUBLIC ASSESSMENT REPORT (EPAR) IBAFLIN" (PDF). European Medicines Agency. 1 September 2007.

Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)

Short-acting	Sulfaisodimidine Sulfamethizole Sulfadimidine (Sulfamethazine, Sulfadimerazine, Sulfadimezine) Sulfapyridine (Sulfasalazine) Sulfafurazole (Acetyl sulfisoxazole) Sulfanilamide Prontosil Sulfathiazole (Phthalylsulfathiazole, Succinylsulfathiazole) Sulfathiourea
Intermediate-acting	Sulfamethoxazole Sulfadiazine Sulfamoxole
Long-acting	Sulfadimethoxine Sulfadoxine Sulfalene Sulfametomidine Sulfametoxydiazine Sulfamethoxypyridazine Sulfaperin Sulfamerazine Sulfaphenazole Sulfamazone
Other/ungrouped	Mafenide Sulfacetamide Sulfaclozine Sulfadicramide Sulfaguanidine Sulfametrole Sulfanitran

Combinations

Other DHPS inhibitors

Quinolones
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)

2nd generation	Ciprofloxacin Ofloxacin Enoxacin Fleroxacin Lomefloxacin Nadifloxacin/Levonadifloxacin/Alalevonadifloxacin Norfloxacin Pefloxacin Rufloxacin
3rd generation	Levofloxacin Balofloxacin Grepafloxacin Pazufloxacin Sparfloxacin Temafloxacin Tosufloxacin
4th generation	Besifloxacin Delafloxacin Gatifloxacin Finafloxacin Gemifloxacin Moxifloxacin Clinafloxacin Garenoxacin Prulifloxacin Sitafloxacin Trovafloxacin/Alatrofloxacin
Veterinary	Danofloxacin Difloxacin Enrofloxacin Ibafloxacin Marbofloxacin Orbifloxacin Pradofloxacin Sarafloxacin

Newer non-fluorinated

Related (DG)

Nitroimidazole derivatives	Secnidazole

RNA synthesis

Rifamycins/ RNA polymerase	Rifampicin Rifabutin Rifapentine Rifaximin Rifalazil
Lipiarmycins	Fidaxomicin

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