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Route 343 was included in the May 2009 sale of Travel London to Abellio London. Abellio London successfully tendered to retain the route with a new contract commencing on 5 May 2011.
In June 2010, the route was revealed to be amongst the ten worst performing in London. Two additional morning peak journeys were introduced on 12 June 2010 with the intention of solving the problems; performance improved as a result, although the route continued to receive complaints.
A proposal to increase the frequency of the route was announced by Transport for London in November 2010.
At 08:22 on 17 March 2012, a bus on route 343 caught fire on Pepys Road, New Cross. The fire was put out by 09:20 and there were no injuries.