Pindone - Misplaced Pages

Pindone
Names

Preferred IUPAC name 2-(2,2-Dimethylpropanoyl)-1H-indene-1,3(2H)-dione
Other names 2-Pivaloyl-1,3-indandione
Identifiers
CAS Number	83-26-1
3D model (JSmol)	Interactive image
ChemSpider	6476
ECHA InfoCard	100.001.330
KEGG	C19141
PubChem CID	6732
UNII	2KFI1XBH7G
CompTox Dashboard (EPA)	DTXSID1025930
InChI InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3Key: RZKYEQDPDZUERB-UHFFFAOYSA-N InChI=1/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3Key: RZKYEQDPDZUERB-UHFFFAOYAX
SMILES O=C2c1ccccc1C(=O)C2C(=O)C(C)(C)C
Properties
Chemical formula	C₁₄H₁₄O₃
Molar mass	230.26 g/mol
Appearance	Bright-yellow powder
Odor	almost none
Density	1.06 g/mL
Melting point	110 °C (230 °F; 383 K)
Solubility in water	0.002% (25°C)
Hazards
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	280 mg/kg (rat, oral) 75 mg/kg (dog, oral) 150 mg/kg (rabbit, oral)
NIOSH (US health exposure limits):
PEL (Permissible)	TWA 0.1 mg/m
REL (Recommended)	TWA 0.1 mg/m
IDLH (Immediate danger)	100 mg/m
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

Pindone is an anticoagulant drug for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

References

^ NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
"Pindone". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID 15694595.