Misplaced Pages

ZD-9379

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Antagonist of the NMDA receptor at the glycine site
ZD-9379
Names
IUPAC name 7-Chloro-2-(4-methoxy-2-methylphenyl)-3,5-dihydropyridazinoquinoline-1,4,10-trione
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
InChI
  • InChI=1S/C19H14ClN3O4/c1-9-7-11(27-2)4-6-14(9)23-19(26)15-16(18(25)22-23)21-13-8-10(20)3-5-12(13)17(15)24/h3-8H,1-2H3,(H,21,24)(H,22,25)Key: PSTDMIAVUUYOOQ-UHFFFAOYSA-N
SMILES
  • CC1=C(C=CC(=C1)OC)N2C(=O)C3=C(C(=O)N2)NC4=C(C3=O)C=CC(=C4)Cl
Properties
Chemical formula C19H14ClN3O4
Molar mass 383.79 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

ZD-9379 is an antagonist of the N-methyl-D-aspartate receptor. It possesses neuroprotective properties and could potentially be used for the treatment of certain strokes.

Mechanism of action

ZD-9379 works by antagonizing (blocking) the glycine site on the NMDA receptor, because both glycine (co-agonist) and an agonist at the main site are needed to activate the NMDA receptor, blocking the glycine binding site prevents the receptor from activating.

Potential use

In rats, ZD-9379 has been tested to help spreading depression and brain infarction, results have shown that treatment with ZD-9379 reduced the amount of spreading depressions and the volume of infarcts. Another study was also able to produce similar results.

References

  1. "ZD 9379 | CAS 170142-20-8 | ZD9379 | Tocris Bioscience".
  2. Danysz, Wojciech; Parsons, Chris G. (March 2002). "Neuroprotective potential of ionotropic glutamate receptor antagonists". Neurotoxicity Research. 4 (2): 119–126. doi:10.1080/10298420290015872. ISSN 1476-3524. PMID 12829411.
  3. Tatlisumak, T.; Takano, K.; Meiler, M. R.; Fisher, M. (2000). "A Glycine Site Antagonist ZD9379 Reduces Number of Spreading Depressions and Infarct Size in Rats with Permanent Middle Cerebral Artery Occlusion". Brain Edema XI. Vol. 76. pp. 331–333. doi:10.1007/978-3-7091-6346-7_68. ISBN 978-3-7091-7257-5. ISSN 0065-1419. PMID 11450037. {{cite book}}: |journal= ignored (help)
  4. Qiu, H.; Hedlund, L. W.; Gewalt, S. L.; Benveniste, H.; Bare, T. M.; Johnson, G. A. (1997). "Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study". Journal of Magnetic Resonance Imaging. 7 (4): 739–744. doi:10.1002/jmri.1880070421. ISSN 1053-1807. PMID 9243396.
Ionotropic glutamate receptor modulators
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Categories: