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{{Use dmy dates|date=August 2021}}
{{chembox {{chembox
| Verifiedfields = changed
| verifiedrevid = 400119970
| Watchedfields = changed
|ImageFile=Ferrous gluconate.png
| verifiedrevid = 406547047
|ImageSize=
| ImageFile = Ferrous gluconate.png
|IUPACName=iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid {{Citation needed|date=April 2010}}
| ImageSize =
|OtherNames=
| SystematicName=Iron; (2''R'',3''R'',4''S'',5''S'')-2,3,4,5,6-pentahydroxyhexanoic acid
|Section1= {{Chembox Identifiers
| OtherNames =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 19953133 | ChemSpiderID = 19953133
| InChI = 1/2C6H12O7.Fe/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1 | InChI = 1/2C6H12O7.Fe/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VRIVJOXICYMTAG-IYEMJOQQSA-L | StdInChIKey = VRIVJOXICYMTAG-IYEMJOQQSA-L
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=299-29-6 {{Citation needed|date=April 2010}}
| CASNo=299-29-6
| PubChem=9291
| UNII_Ref = {{fdacite|correct|FDA}}
| SMILES = .O((O)C()=O)(O)(O)CO.C(=O)(O)(O)(O)(O)CO
| UNII = 781E2AXH0K
}}
| PubChem = 9291
|Section2= {{Chembox Properties
| SMILES = .O((O)C()=O)(O)(O)CO.C(=O)(O)(O)(O)(O)CO}}
| Formula=C<sub>12</sub>H<sub>24</sub>FeO<sub>14</sub>
|Section2={{Chembox Properties
| MolarMass=448.156
| Formula = FeC<sub>12</sub>H<sub>22</sub>O<sub>14</sub>
| Appearance=
| MolarMass = 446,14528 g/mol
| Density=
| Appearance = light yellow to brown powder
| MeltingPt=
| Odor = slight caramel odor
| BoilingPt=
| MeltingPtC= 188
| Solubility=
| MeltingPt_notes = dihydrate
}}
| Solubility = soluble
|Section3= {{Chembox Hazards
| SolubleOther = soluble in ]<br>negligible in ]}}
| ExternalMSDS =
|Section6={{Chembox Pharmacology
| FlashPt=
| ATCCode_prefix = B03
| Autoignition=
| ATCCode_suffix = AA03
}}
| ATC_Supplemental = <br>{{ATC|B03|AD05}} (combination with ])}}
}}
|Section7={{Chembox Hazards
'''Iron(II) gluconate''', or '''ferrous gluconate''',<ref></ref> is a black compound often used as an iron supplement. It is the iron(II) salt of ]. It is marketed under brand names such as ''Fergon'', ''Ferralet'', and ''Simron''.<ref></ref> It is also present in the combination supplement ], a vitamin mixture created by ] and used in the religion ].<ref name="all-about-radiation">{{cite book | last = Hubbard | first = L. Ron | isbn = 9780884040620 | title = ] }}</ref>
| ExternalSDS = }}}}
'''Iron(II) gluconate''', or '''ferrous gluconate''',<ref></ref> is a black compound often used as an iron supplement. It is the iron(II) salt of ]. It is marketed under brand names such as ''Fergon'', ''Ferralet'' and ''Simron''.<ref></ref>


== Uses == ==Uses==
===Medical===
Ferrous gluconate is effectively used in the treatment of ]. The use of this compound compared with other ] preparations results in satisfactory ] responses, a high percentage utilization of iron, and daily increase in ] that a normal level occurs in a reasonably short time.<ref>{{cite journal |author=Paul Reznikoff and Walther F. Goebel |year=1937 |month=July |title=THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA |journal=J Clin Invest. |pmid=16694502 |volume=16 |issue=4 |pmc=424894 |pages=547–554 |doi=10.1172/JCI100881 |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC424894/pdf/jcinvest00545-0065.pdf |accessdate=2010-02-10}}</ref>
{{Main|Iron supplement}}
Ferrous gluconate is effectively used in the treatment of ]. The use of this compound compared with other ] preparations results in satisfactory ] responses, a high percentage utilization of iron, and daily increase in ] that a normal level occurs in a reasonably short time.<ref>{{cite journal | doi=10.1172/JCI100881 | title=The Use of Ferrous Gluconate in the Treatment of Hypochromic Anemia | year=1937 | last1=Reznikoff | first1=Paul | last2=Goebel | first2=Walther F. | journal=Journal of Clinical Investigation | volume=16 | issue=4 | pages=547–54 | pmid=16694502 | pmc=424894}}</ref>


===Food additive===
Ferrous gluconate is also used as a ] when processing black ]s. It imparts a uniform jet black colour to the olives.<ref></ref>
Ferrous gluconate is also used as a ] when processing black ]s. It is represented by the food labeling ] E579 in Europe. It imparts a uniform jet black color to the olives.<ref></ref><ref>Antonio Higinio Sánchez Gómez, Pedro García García and Luis Rejano Navarro (Spain 2006). "", p. 92, from digital.csic.es. 2018-04-22. Retrieved 2019-03-01.</ref>


== Toxicity == ==Toxicity==
Ferrous gluconate may be toxic in case of overdose. Children may show signs of toxicity with ingestions of 10–20&nbsp;mg/kg of elemental iron. Serious toxicity may result from ingestions of more than 60&nbsp;mg/kg. Iron exerts both local and systemic effects and is corrosive to the GI ] and can have a negative impact on the heart and blood (], low ], fast and weak pulse, ]), lungs, liver, gastrointestinal system (diarrhea, nausea, vomiting blood), nervous system (chills, dizziness, ], convulsions, headache), and skin (flushing, loss of color, bluish-colored lips and fingernails).<ref> Ferrous gluconate may be ] in case of overdose. Children may show signs of toxicity with ingestions of 10–20&nbsp;mg/kg of elemental iron. Serious toxicity may result from ingestions of more than 60&nbsp;mg/kg. Iron exerts both local and systemic effects: it is corrosive to the gastrointestinal ], it can have a negative impact on the heart and blood (], low ], fast and weak pulse, ]), lungs, liver, gastrointestinal system (diarrhea, nausea, vomiting blood), nervous system (chills, dizziness, ], convulsions, headache), and skin (flushing, loss of color, bluish-colored lips and fingernails).<ref></ref><ref></ref> The symptoms may disappear in a few hours, but then emerge again after 1 or more days. {{citation needed|date=February 2016}}
</ref><ref></ref> The symptoms may disappear in a few hours, but then emerge again after 1 or more days.


==See also==
== Compendial status ==
* ] <ref name=ib29>{{cite web
| last = The British Pharmacopoeia Secretariat
| first =
| authorlink =
| coauthors =
| title = Index, BP 2009
| work =
| publisher =
| year = 2009
| url = http://www.pharmacopoeia.co.uk/pdf/2009_index.pdf
| format =
| doi =
| accessdate = 5 July 2009 }}</ref>
{{Expand section|date=April 2010}}


*]
==Notes and references==
*]

==References==
<references/> <references/>


{{Iron compounds}}
== See also ==
{{Antianemic preparations}}
* ]
{{Use dmy dates|date=January 2011}}


{{DEFAULTSORT:Iron(Ii) Gluconate}}
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] ]
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]

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Latest revision as of 13:35, 14 January 2022

Iron(II) gluconate
Names
Systematic IUPAC name Iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.131.978 Edit this at Wikidata
E number E579 (acidity regulators, ...)
PubChem CID
UNII
InChI
  • InChI=1S/2C6H12O7.Fe/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1Key: VRIVJOXICYMTAG-IYEMJOQQSA-L
  • InChI=1/2C6H12O7.Fe/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1Key: VRIVJOXICYMTAG-QFKJHGNTBV
SMILES
  • .O((O)C()=O)(O)(O)CO.C(=O)(O)(O)(O)(O)CO
Properties
Chemical formula FeC12H22O14
Molar mass 446,14528 g/mol
Appearance light yellow to brown powder
Odor slight caramel odor
Melting point 188 °C (370 °F; 461 K) dihydrate
Solubility in water soluble
Solubility soluble in glycerin
negligible in alcohol
Pharmacology
ATC code B03AA03 (WHO)
B03AD05 (WHO) (combination with folic acid)
Hazards
Safety data sheet (SDS) Oxford MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Iron(II) gluconate, or ferrous gluconate, is a black compound often used as an iron supplement. It is the iron(II) salt of gluconic acid. It is marketed under brand names such as Fergon, Ferralet and Simron.

Uses

Medical

Main article: Iron supplement

Ferrous gluconate is effectively used in the treatment of hypochromic anemia. The use of this compound compared with other iron preparations results in satisfactory reticulocyte responses, a high percentage utilization of iron, and daily increase in hemoglobin that a normal level occurs in a reasonably short time.

Food additive

Ferrous gluconate is also used as a food additive when processing black olives. It is represented by the food labeling E number E579 in Europe. It imparts a uniform jet black color to the olives.

Toxicity

Ferrous gluconate may be toxic in case of overdose. Children may show signs of toxicity with ingestions of 10–20 mg/kg of elemental iron. Serious toxicity may result from ingestions of more than 60 mg/kg. Iron exerts both local and systemic effects: it is corrosive to the gastrointestinal mucosa, it can have a negative impact on the heart and blood (dehydration, low blood pressure, fast and weak pulse, shock), lungs, liver, gastrointestinal system (diarrhea, nausea, vomiting blood), nervous system (chills, dizziness, coma, convulsions, headache), and skin (flushing, loss of color, bluish-colored lips and fingernails). The symptoms may disappear in a few hours, but then emerge again after 1 or more days.

See also

References

  1. SciToys.com ferrous gluconate information page
  2. Drugs.com ferrous gluconate summary
  3. Reznikoff, Paul; Goebel, Walther F. (1937). "The Use of Ferrous Gluconate in the Treatment of Hypochromic Anemia". Journal of Clinical Investigation. 16 (4): 547–54. doi:10.1172/JCI100881. PMC 424894. PMID 16694502.
  4. CSPI's Guide to Food Additives
  5. Antonio Higinio Sánchez Gómez, Pedro García García and Luis Rejano Navarro (Spain 2006). "Elaboration of table olives – 4.2.3. Colour fixation", p. 92, from digital.csic.es. Archived 2018-04-22. Retrieved 2019-03-01.
  6. Toxicity, Iron
  7. Iron overdose
Iron compounds
Fe(−II)
Fe(0)
Fe(I)
Organoiron(I) compounds
  • (C5H5FeCO)2(CO)2
    • Fe(0,II)
    Fe(II)
    Organoiron(II) compounds
    Fe(0,III)
    Fe(II,III)
    Fe(III)
    Organoiron(III) compounds
    Fe(IV)
    Fe(VI)
    Purported
    sort
    Antianemic preparations (B03)
    Erythropoietins
    Iron supplements
    Vitamin B12 and
    folic acid supplements
    HIF prolyl-hydroxylase inhibitors
    Other
    Categories: