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Spiroxatrine: Difference between revisions

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{{chembox {{chembox
| Verifiedfields = changed | Verifiedfields = changed
| UNII_Ref = {{fdacite|changed|FDA}} | Watchedfields = changed
⚫ | verifiedrevid = 470470273
⚫ | ImageFile = Spiroxatrine.svg
⚫ | ImageSize = 225
⚫ | IUPACName = 8-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-1-phenyl-1,3,8-triazaspirodecan-4-one
⚫ | OtherNames =

⚫ | Section1 = {{Chembox Identifiers
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = DR0QR50ALL | UNII = DR0QR50ALL
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | verifiedrevid = 418121034
⚫ |ImageFile=Spiroxatrine.svg
⚫ |ImageSize=
⚫ |IUPACName=8-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-1-phenyl-1,3,8-triazaspirodecan-4-one
⚫ |OtherNames=
⚫ |Section1={{Chembox Identifiers
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 5078 | ChemSpiderID = 5078
| InChI = 1/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)
| InChIKey = JVGBTTIJPBFLTE-UHFFFAOYAW
| ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 300555 | ChEMBL = 300555
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JVGBTTIJPBFLTE-UHFFFAOYSA-N | StdInChIKey = JVGBTTIJPBFLTE-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo=1054-88-2 | CASNo = 1054-88-2
| PubChem=5268 | PubChem = 5268
| IUPHAR_ligand = 53 | IUPHAR_ligand = 53
| SMILES = O=C2NCN(c1ccccc1)C23CCN(CC3)CC4Oc5ccccc5OC4 | SMILES = O=C2NCN(c1ccccc1)C23CCN(CC3)CC4Oc5ccccc5OC4
| MeSHName=Spiroxatrine | MeSHName = Spiroxatrine
}} }}

|Section2={{Chembox Properties | Section2 = {{Chembox Properties
| C=22|H=25|N=3|O=3 | C=22 | H=25 | N=3 | O=3
| Appearance=
| Appearance =
| Density=
| Density =
| MeltingPt=
| MeltingPt =
| BoilingPt=
| BoilingPt =
| Solubility=
| Solubility =
}} }}

|Section3={{Chembox Hazards | Section3 = {{Chembox Hazards
| MainHazards=
| MainHazards =
| FlashPt=
| FlashPt =
| Autoignition=
| AutoignitionPt =
}} }}
}} }}
⚫ '''Spiroxatrine''' is drug which acts as a selective ] at both the ] and the ] ]. It is an ] of ], and also has some ] effects.


⚫ '''Spiroxatrine''' is a drug which acts as a selective ] at both the ] and the ] ].<ref>{{Cite journal | pmid = 8105762 | year = 1993 | last1 = Terrón | first1 = J. A. | title = The alpha-antiadrenergic properties of spiroxatrine, a ligand of serotonergic 5-HT1A receptors | journal = Archivos del Instituto de Cardiología de México | volume = 63 | issue = 4 | pages = 289–95 | last2 = Ibarra | first2 = M | last3 = Ransanz | first3 = V | last4 = Hong | first4 = E | last5 = Villalón | first5 = C. M. }}</ref> It is an ] of ] and also has some ] effects.


== References == ==References==
{{reflist}} {{Reflist}}


{{Navboxes
{{Dopaminergics}}
| title = ]
{{Serotonergics}}
| titlestyle = background:#ccccff
| list1 =
{{Adrenergic receptor modulators}}
{{Dopamine receptor modulators}}
{{Serotonin receptor modulators}}
{{Xenobiotic-sensing receptor modulators}}
}}


] ]
] ]
] ]
]
]
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{{nervous-system-drug-stub}} {{Nervous-system-drug-stub}}

Latest revision as of 04:24, 4 November 2022

Spiroxatrine
Names
IUPAC name 8-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-1-phenyl-1,3,8-triazaspirodecan-4-one
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
IUPHAR/BPS
MeSH Spiroxatrine
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)Key: JVGBTTIJPBFLTE-UHFFFAOYSA-N
SMILES
  • O=C2NCN(c1ccccc1)C23CCN(CC3)CC4Oc5ccccc5OC4
Properties
Chemical formula C22H25N3O3
Molar mass 379.460 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Spiroxatrine is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamine antagonist effects.

References

  1. Terrón, J. A.; Ibarra, M; Ransanz, V; Hong, E; Villalón, C. M. (1993). "The alpha-antiadrenergic properties of spiroxatrine, a ligand of serotonergic 5-HT1A receptors". Archivos del Instituto de Cardiología de México. 63 (4): 289–95. PMID 8105762.
Pharmacodynamics
Adrenergic receptor modulators
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
Dopamine receptor modulators
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
Serotonin receptor modulators
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3–7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Xenobiotic-sensing receptor modulators
CARTooltip Constitutive androstane receptor
PXRTooltip Pregnane X receptor
See also
Receptor/signaling modulators


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