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Butidrine

Clinical data
Trade names	Betabloc, Butidrate, Recetan
Other names	Butedrine; Butydrine; Hydrobutamine; Idrobutamine
Drug class	Beta blocker
Identifiers
IUPAC name 2-(butan-2-ylamino)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanol
CAS Number	7433-10-5
PubChem CID	15177
ChemSpider	14445
UNII	N2S0PKP5L5
ChEBI	CHEBI:135008
ChEMBL	ChEMBL358930
CompTox Dashboard (EPA)	DTXSID40864062
Chemical and physical data
Formula	C16H25NO
Molar mass	247.382 g·mol
3D model (JSmol)	Interactive image
SMILES CCC(C)NCC(C1=CC2=C(CCCC2)C=C1)O
InChI InChI=1S/C16H25NO/c1-3-12(2)17-11-16(18)15-9-8-13-6-4-5-7-14(13)10-15/h8-10,12,16-18H,3-7,11H2,1-2H3 Key:GVNYSERWAKVROD-UHFFFAOYSA-N

Butidrine (INNTooltip International Nonproprietary Name), sold under the brand names Betabloc, Butidrate, and Recetan among others, is a beta blocker (or β-adrenergic receptor antagonist) related to pronethalol and propranolol that was developed in the 1960s. It is not cardioselective (i.e., is not selective for the β₁-adrenergic receptor over the β₂-adrenergic receptor). It has membrane stabilizing activity but no intrinsic sympathomimetic activity (i.e., partial agonist activity). Similarly to certain other beta blockers, butidrine additionally possesses local anesthetic properties.

References

1. Bristol JA (1986). Cardiovascular drugs. John Wiley & Sons, Incorporated. p. 111. ISBN 978-0-471-09228-5.
2. Drug Metabolism Reviews. Marcel Dekker. 1972.
3. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 58–. ISBN 978-94-011-4439-1.
4. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 197–. ISBN 978-1-4757-2085-3.
5. Sokabe, Hirofumi (1985). "A new classification of β-adrenoceptor blocking drugs". Trends in Pharmacological Sciences. 6: 107–109. doi:10.1016/0165-6147(85)90051-3.
6. Fitzgerald JD (1969). "Perspectives in adrenergic beta-receptor blockade". Clin Pharmacol Ther. 10 (3): 292–306. doi:10.1002/cpt1969103292. PMID 4894830.
7. Charlier R (1971). Antianginal drugs: pathophysiological, haemodynamic, methodological, pharmacological, biochemical and clinical basis for their use in human therapeutics. Springer-Verlag. ISBN 978-3-540-05365-1.

• Beta blockers
• Local anesthetics
• Phenylethanolamines
• Sodium channel blockers
• Tetralins