Orbifloxacin: Difference between revisions

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Revision as of 16:17, 20 October 2011 editCheMoBot (talk \| contribs)Bots141,565 edits Updating {{drugbox}} (changes to verified fields - updated 'ChEBI_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report errors or bugs)← Previous edit		Latest revision as of 11:41, 21 October 2024 edit undoJWBE (talk \| contribs)Extended confirmed users10,127 edits removed Category:Cyclopropanes; added Category:Cyclopropyl compounds using HotCat
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			{{Short description\|Chemical compound}}
	{{Drugbox		{{Drugbox
	\| Verifiedfields = changed		\| Verifiedfields = changed
	\| verifiedrevid = ~~408780687~~		\| verifiedrevid = 462265582
	\| IUPAC_name = 1-Cyclopropyl-7--5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid		\| IUPAC_name = 1-Cyclopropyl-7--5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
	\| image = orbifloxacin.png		\| image = orbifloxacin.png

	<!--Clinical data-->		<!--Clinical data-->
	\| tradename =		\| tradename =
	\| Drugs.com = {{drugs.com\|international\|orbifloxacin}}		\| Drugs.com = {{drugs.com\|international\|orbifloxacin}}
	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->		\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
	\| pregnancy_US = <!-- A / B / C / D / X -->		\| pregnancy_US = <!-- A / B / C / D / X -->
	\| pregnancy_category =		\| pregnancy_category =
	\| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->		\| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
	\| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->		\| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
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	<!--Pharmacokinetic data-->		<!--Pharmacokinetic data-->
	\| bioavailability =		\| bioavailability =
	\| protein_bound =		\| protein_bound =
	\| metabolism =		\| metabolism =
	\| elimination_half-life =		\| elimination_half-life =
	\| excretion =		\| excretion =

	<!--Identifiers-->		<!--Identifiers-->
	\| CAS_number_Ref = {{cascite\|~~correct~~\|??}}		\| CAS_number_Ref = {{cascite\|changed\|??}}
	\| CAS_number = 113617-63-3		\| CAS_number = 113617-63-3
	\| ATCvet = yes		\| ATCvet = yes
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	\| PubChem = 60605		\| PubChem = 60605
	\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}		\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}
	\| DrugBank =		\| DrugBank =
	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
	\| ChemSpiderID = 54631		\| ChemSpiderID = 54631
	\| UNII_Ref = {{fdacite\|~~changed~~\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = 660932TPY6		\| UNII = 660932TPY6
	\| KEGG_Ref = {{keggcite\|correct\|kegg}}		\| KEGG_Ref = {{keggcite\|correct\|kegg}}
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	<!--Chemical data-->		<!--Chemical data-->
	\| C=19 \| H=20 \| F=3 \| N=3 \| O=3		\| C=19 \| H=20 \| F=3 \| N=3 \| O=3
		⚫	\| smiles = O=C(O)C1=CN(C2CC2)c3c(C1=O)c(F)c(F)c(c3F)N4C(C)N(C)C4
	\| molecular_weight = 395.37 g/mol
⚫	\| smiles = ~~Fc1c~~(~~c(F~~)~~c2c~~(~~c1F~~)C(=O)C(\C(=O)~~O)=C/N2C3CC3~~)N4C(N(~~C4)~~C)C
	\| InChI = 1/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+
	\| InChIKey = QIPQASLPWJVQMH-DTORHVGOBR
	\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}		\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChI = 1S/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+		\| StdInChI = 1S/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+
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	}}		}}

	'''Orbifloxacin''' (brand name '''Orbax''') is a ] ] which is approved for use in dogs,<ref>. ~~Retrieved~~ on ~~June~~ ~~23,~~ 2008.</ref> marketed by ].		'''Orbifloxacin''' (brand name '''Orbax''') is a ] ] which is approved for use in dogs,<ref>{{cite web \| url = http://dil.vetmed.vt.edu/Display/NadaBrowse.cfm?NadaString=141-081 \| title = Product Abstract - NADA 141-081 \| access-date = 21 June 2008 \| publisher = American College of Veterinary Clinical Pharmacology \| url-status = }}{{deadlink\|date=September 2023}}</ref><ref>{{cite book \| vauthors = Papich MG \| chapter = Orbifloxacin \| chapter-url = https://books.google.com/books?id=MVcBEAAAQBAJ&pg=PA674 \| page = 674 \| title=Papich Handbook of Veterinary Drugs \|date= October 2020 \|location=St. Louis, Missouri \| publisher = Elsevier Health Sciences \|isbn=978-0-323-70958-3 \|edition=Fifth}}</ref> marketed by ].

	==See also==		==See also==
			]
	*]
			* ]
	*]

	==References==		==References==
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	]		]
	]		]
	]		]
			]
	]

Latest revision as of 11:41, 21 October 2024

Chemical compound Pharmaceutical compound

Orbifloxacin
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATCvet code	QJ01MA95 (WHO)
Legal status
Legal status	Veterinary use only
Identifiers
IUPAC name 1-Cyclopropyl-7--5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS Number	113617-63-3
PubChem CID	60605
ChemSpider	54631
UNII	660932TPY6
KEGG	D08299
ChEMBL	ChEMBL295433
CompTox Dashboard (EPA)	DTXSID7046201
ECHA InfoCard	100.166.510
Chemical and physical data
Formula	C₁₉H₂₀F₃N₃O₃
Molar mass	395.382 g·mol
3D model (JSmol)	Interactive image
SMILES O=C(O)C1=CN(C2CC2)c3c(C1=O)c(F)c(F)c(c3F)N4C(C)N(C)C4
InChI InChI=1S/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+ Key:QIPQASLPWJVQMH-DTORHVGOSA-N
(what is this?) (verify)

Orbifloxacin (brand name Orbax) is a fluoroquinolone antibiotic which is approved for use in dogs, marketed by Schering-Plough Animal Health.

References

"Product Abstract - NADA 141-081". American College of Veterinary Clinical Pharmacology. Retrieved 21 June 2008.
Papich MG (October 2020). "Orbifloxacin". Papich Handbook of Veterinary Drugs (Fifth ed.). St. Louis, Missouri: Elsevier Health Sciences. p. 674. ISBN 978-0-323-70958-3.

Antibacterials that inhibit nucleic acid (J01E, J01M)

Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)

DHFR inhibitor

2,4-Diaminopyrimidine

Sulfonamides
(DHPS inhibitor)

Short-acting	Sulfaisodimidine Sulfamethizole Sulfadimidine (Sulfamethazine, Sulfadimerazine, Sulfadimezine) Sulfapyridine (Sulfasalazine) Sulfafurazole (Acetyl sulfisoxazole) Sulfanilamide Prontosil Sulfathiazole (Phthalylsulfathiazole, Succinylsulfathiazole) Sulfathiourea
Intermediate-acting	Sulfamethoxazole Sulfadiazine Sulfamoxole
Long-acting	Sulfadimethoxine Sulfadoxine Sulfalene Sulfametomidine Sulfametoxydiazine Sulfamethoxypyridazine Sulfaperin Sulfamerazine Sulfaphenazole Sulfamazone
Other/ungrouped	Mafenide Sulfacetamide Sulfaclozine Sulfadicramide Sulfaguanidine Sulfametrole Sulfanitran

Combinations

Other DHPS inhibitors

Quinolones
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)

1st generation

Fluoroquinolones

2nd generation	Ciprofloxacin Ofloxacin Enoxacin Fleroxacin Lomefloxacin Nadifloxacin/Levonadifloxacin/Alalevonadifloxacin Norfloxacin Pefloxacin Rufloxacin
3rd generation	Levofloxacin Balofloxacin Grepafloxacin Pazufloxacin Sparfloxacin Temafloxacin Tosufloxacin
4th generation	Besifloxacin Delafloxacin Gatifloxacin Finafloxacin Gemifloxacin Moxifloxacin Clinafloxacin Garenoxacin Prulifloxacin Sitafloxacin Trovafloxacin/Alatrofloxacin
Veterinary	Danofloxacin Difloxacin Enrofloxacin Ibafloxacin Marbofloxacin Orbifloxacin Pradofloxacin Sarafloxacin

Newer non-fluorinated

Related (DG)

Aminocoumarins: Novobiocin

Anaerobic DNA
inhibitors

Nitroimidazole derivatives	Secnidazole

RNA synthesis

Rifamycins/ RNA polymerase	Rifampicin Rifabutin Rifapentine Rifaximin Rifalazil
Lipiarmycins	Fidaxomicin

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

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Categories:

Latest revision as of 11:41, 21 October 2024

See also

References